三叶汤合复方甲氧那明治疗风燥犯肺型感染后咳嗽临床观察
2017,49(10):38-40
摘要：目的:观察三叶汤合复方甲氧那明治疗风燥犯肺型感染后咳嗽(PIC)的临床疗效。方法:将60例风燥犯肺型PIC患者随机分为3组,A组给予三叶汤加复方甲氧那明胶囊治疗,B组给予三叶汤加复方甲氧那明安慰剂胶囊治疗,C组给予中药安慰剂加复方甲氧那明胶囊治疗,3组均用药10天。观察3组治疗前后咳嗽积分、痰量积分及血清中P物质(SP)、白细胞介素-4(IL-4)浓度的变化,评估治疗效果。结果:总有效率A组95.0%,B组65.0%,C组70.0%,A组的总有效率高于B、C2组,差异均有统计学意义(P<0.05)。治疗后,3组痰量积分及咳嗽积分均较治疗前降低(P<0.05)。与B、C2组治疗后比较,A组的痰量积分及咳嗽积分均下降更明显(P<0.05)。治疗后,3组IL-4及SP浓度均较治疗前下降(P<0.05),A组IL-4、SP浓度下降比B、C2组更明显(P<0.05)。结论:三叶汤合复方甲氧那明治疗风燥犯肺型PIC疗效显著,作用机制可能与降低血液中SP及IL-4浓度有关。
关键词：感染后咳嗽(PIC); 风燥犯肺型; 三叶汤; 复方甲氧那明胶囊; P物质(SP); 白细胞介素-4(IL-4);
Abstract：Adjective：To observe the clinical effect of Sanye tang combined with compound methoxyphenamine capsules for postinfectious cough(PIC)patients with syndrome of wind dryness invading lung.Methods：Divided 60 cases of PIC patients with syndrome of wind dryness invading lung into three groups randomly.The group A was treated with Sanye tang combined with compound methoxyphenamine capsules，while the group B was treated with Sanye tang combined with compound methoxyphenamine placebo capsules and the group C was treated with Chinese medicine placebo combined with compound methoxyphenamine capsules.The three groups all received medication for 10 days.Observed change of cough score，sputum volume score，and levels of substance P(SP)and Interleukin-4(IL-4)of the three groups before and after treatment，and evaluated the curative effect.Results：The total effective rate was 95.0% ，65.0%and 70.0%in the group A，group B and group C respectively，which shows that the total effective rate of the group A was higher than that of the group B and group C，differences being significant(P＜0.05).After treatment，sputum volume scores and cough scores of the three groups were all lower than those before treatment(P＜0.05).Compared with the group B and group C，decline of sputum volume of the group A was more significant(P＜0.05).After treatment，concentration of SP in blood and IL-4 in the three groups was all lower than that before treatment(P＜0.05)，and the decline of the concentration of SP in blood and IL-4 in the group A was more significant than that in the group B and group C(P＜0.05).Conclusion：Sanye tang combined with compound methoxyphenamine capsules has clinical efficacy in treating PIC with syndrome of wind dryness invading lung，and the mechanism may be related to its actions of reducing concentration of SP in blood and IL-4.
Key words：Postinfectious cough (PIC)；Syndrome ofwind dryness invading lung；Sanye tang；Compound methoxyphenamine capsules；Substance P(SP)；Interleukin-4(IL-4)
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