中西医结合治疗急性重症胰腺炎效果观察
2017,49(10):46-49
摘要：目的:观察中西医结合治疗急性重症胰腺炎患者的效果。方法:将102例急性重症胰腺炎患者随机分为2组,对照组50例采用常规治疗,观察组52例以常规疗法联合中药通腑清胰方治疗,5天为1疗程,治疗2疗程。比较2组患者的肛门排气时间、排便时间、肠鸣音恢复时间、腹痛腹胀缓解时间,治疗前后检测血淀粉酶(AMY)、血肌酐(SCr)、尿素氮(BUN)等生化指标和肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)等炎症指标的水平。结果:治疗后,观察组肛门排气时间、排便时间、肠鸣音恢复时间、腹痛腹胀缓解时间均较对照组缩短,差异均有统计学意义(P<0.05)。2组AMY、BUN、SCr和TNF-α、hs-CRP、IL-6水平均较治疗前降低,差异均有统计学意义(P<0.05);观察组各指标水平均低于对照组,差异均有统计学意义(P<0.05)。结论:采用常规疗法联合通腑清胰方治疗急性重症胰腺炎效果显著,可有效抑制炎症反应,并促进胃肠功能的恢复。
关键词：急性重症胰腺炎; 中西医结合疗法; 通腑清胰方; 炎症因子; 生化指标;
Abstract：Objective：To observe the effect of integrated Chinese and western medicine therapy for severe acute pancreatitis.Methods：Divided 102 patients with severe acute pancreatitis into two groups randomly.The 50 cases in the control group were given the routine treatment，while the 52 cases in the observation group were given Tongfu Qinyi prescription based on routine therapy.One course lasted for five days，and treatment of both groups lasted for two courses.Compared time of anal exhaust，defecating，bowel sounds recovery，abdominal distention and abdominal pain relieve in both group，detected level of Amylase(AMY)，serum creatinine(SCr)，blood urea nitrogen(BUN)and tumor necrosis factor- α(TNF-α)，interleukin-6(IL-6)，high sensitive C-reactive protein(hs-CRP).Results：After treatment，time of anal exhaust，defecating，bowel sounds recovery，abdominal distention and abdominal pain relieve in the observation group was all shorter than that of the control group，difference being significant(P＜0.05).Levels of AMY，BUN，SCr，and TNF-α，hs-CRP，IL-6 in both groups were all lower than those before treatment(P＜0.05)；levels of every index in the observation group were lower than that of the control group，difference being significant(P＜0.05).Conclusion：The combination of routine therapy and Tongfu Qinyi prescription has significant effect in treating severe acute pancreatitis，which can inhibit inflammatory reaction and promote recovery of gastrointestinal function.
Key words：Severe acute pancreatitis；Integrated Chinese and western medicine therapy；Tongfu Qinyi prescription；Inflammatory factor；Biochemical index
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