益肾祛痰化瘀汤联合常规疗法治疗血管性痴呆临床观察
2017,49(10):49-51
摘要：目的:观察益肾祛痰化瘀汤联合常规疗法治疗血管性痴呆患者的临床疗效。方法:将84例肾虚兼痰浊瘀阻型患者随机分为2组,对照组口服盐酸多奈哌齐片治疗,治疗组在对照组基础上加服益肾祛痰化瘀汤,2组均连续治疗4周。观察2组的临床疗效,治疗前后评定简易智能量表(MMSE)、长谷川痴呆量表(HDS)、日常生活能力量表(ADL)评分,检测血清炎性因子超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)。结果:治疗后,对照组总有效率70.0%,治疗组总有效率95.0%,2组比较,差异有统计学意义(P<0.05)。2组MMSE、HDS评分均较治疗前升高(P<0.05),ADL评分均降低(P<0.05);治疗组3项量表评分与对照组比较,差异均有统计学意义(P<0.05)。2组hs-CRP、Hcy、TNF-α水平均较治疗前降低(P<0.05);治疗组3项指标水平均低于对照组,差异均有统计学意义(P<0.05)。结论:在常规疗法基础上加服益肾祛痰化瘀汤治疗肾虚兼痰浊瘀阻型血管性痴呆,可提高患者的认知功能、智能和日常生活活动能力,并减轻炎症反应,疗效较好。
关键词：血管性痴呆; 肾虚兼痰浊瘀阻型; 中西医结合疗法; 益肾祛痰化瘀汤; 简易智能量表(MMSE); 长谷川痴呆量表(HDS); 日常生活能力量表(ADL); 炎性因子;
Abstract：Objective：To observe the clinical effect of Yishen Qutan Huayu tang combined with routine therapy for vascular dementia.Methods：Divided 84 cases of patients with kidney deficiency and turbid，phlegm，blood stagnation type into two groups randomly.Both groups were given donepezil hydrochloride tablets orally，while the treatment group was additionally treated with Yishen Qutan Huayu tang.Both groups received treatment for four weeks continuously.Observed the clinical effect，assessed scores of mini-mental state examination(MMSE)，Hasegawa dementia scale(HDS)and activity of daily living(ADL)，and determined serum inflammatory factorsincluding high sensitive C-reactiveprotein(hs-CRP)，homocysteine(Hcy)and tumor necrosis factor-α(TNF-α)in both groups.Results：After treatment，the total effective rate was 70.0%in the control group，and 95.0%in the treatment group，the difference being significant(P＜0.05).Scores of MMSE and HDS in both groups were increased when compared with those before treatment，while ADL scores in both groups were decreased when compared with those before treatment(P＜0.05).Compared the three scores in the observation group with those in the control group，differences were significant(P＜0.05).Levels of hs-CRP，Hcy and TNF-α in both groups were declined，comparing with those before treatment(P＜0.05)，and the three indexes in the treatment group were all lower than those in the control group，differences all being significant(P＜0.05).Conclusion：The therapy of Yishen Qutan Huayu tang based on routine therapy for patients of kidney deficiency and turbid，phlegm，blood stagnation type can effectively enhance cognitive function，mental state and ADL as well as reduce inflammatory reaction of patients，which has better curative effect.
Key words：Vascular dementia；Kidney deficiency and turbid，phlegm，blood stagnation type；Integrated Chinese and western medicine therapy；Yishen Qutan Huayu tang；Mini-mental state examination(MMSE)；Hasegawa dementia scale(HDS)；Activity of daily living(ADL)；Inflammatory factors
收稿日期：
基金项目：
