Objective：To observe heart rate variability indexes in type 2 diabetes senile patients with different Chinese medicine constitution in Yuexiu district of Guangzhou city，and to discussthe constitution typesbe susceptible to cardiovascular autonomic neuropathy.Methods：Divided type 2 diabetes senile patients into 9 types in terms of Chinese medicine constitution，and detected heart rate variability indexes among them.Results：Comparing with those in balanced constitution，both standard deviation of normal-to-normal intervals(SDNN)and standard deviation of abnormal-to-normal intervals(SDANN)in qi-deficiency constitution，yang-deficiency constitution，phlegm-dampness constitution，dampnessheat constitution，and blood-stasis constitution were decreased(P ＜ 0.05，P ＜ 0.01)，while root mean square of successive differences(RMSSD)in yang-deficiency constitution were increased(P＜0.05)，and RMSSD in yin-deficiency constitution and blood-stasis constitution were decreased(P＜0.05，P＜0.01).In comparison with those in balanced constitution，both low frequency(LF)and high frequency(HF)in qi-deficiency constitution， yin-deficiency constitution， phlegm-dampness constitution，dampness-heat constitution，and blood-stasis constitution were declined(P＜0.05，P＜0.01).The ratios of low frequency and high frequency(LF/HF)in yang-deficiency constitution and phlegm-dampness constitution was both reduced(P＜0.01)，while LF/HF in dampness-heat constitution and blood-stasis constitution was both increased(P＜0.01).Conclusion：For theelderly people who have not yet developed diabetes， especially for those with qi-deficiency constitution，yin-deficiency constitution and phlegm-dampness constitution，precautions must be taken.For the senile diabetes patients with qi-deficiency constitution，phlegm-dampness constitution，dampness-heat constitution，yin-deficiency constitution，and blood-stasis constitution，especially those patients with the last three constitution types，it is beneficial to prevent the occurrence and development of cardiovascular autonomic neuropathy by improving their constitutions，controlling blood glucose，adjusting diet，regulating daily schedule，and taking exercises.