桂枝附子汤联合西医常规疗法治疗类风湿关节炎临床观察
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R593.22

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Clinical Observation of Guizhi Fuzi Tang Combined with Routine Western Therapy for Rheumatoid Arthritis
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    摘要:

    目的:观察桂枝附子汤联合西医常规疗法治疗类风湿性关节炎的临床疗效。方法:将96例类风湿性关节炎患者分为联合组及对照组各48例。对照组采用西医常规疗法,联合组在对照组治疗方案的基础上给予桂枝附子汤治疗。比较2组患者主要症状的变化(肿胀关节数、疼痛关节数、晨僵时间)。采用视觉模拟评分法(VAS)评估患者的疼痛程度。采用类风湿性关节炎疾病活动度(DAS28) 评估患者病情变化。检测2组患者治疗前后超敏C-反应蛋白(hs-CRP)、类风湿因子(RF)、血沉(ESR)、白细胞介素-17(IL-17)、肿瘤坏死因子配体相关分子1A(TL1A)的水平。结果:2组临床疗效比较,差异有统计学意义(P<0.05),联合组疗效优于对照组。2组治疗后肿胀关节数、疼痛关节数、晨僵时间、VAS评分、DAS28评分较治疗前均明显降低,差异均有统计学意义(P<0.05);治疗后,联合组肿胀关节数、疼痛关节数、晨僵时间、VAS评分、DAS28评分均低于对照组,差异均有统计学意义(P<0.05);2组治疗后hs-CRP、RF、ESR、IL-17、TL1A较治疗前均明显降低,差异均有统计学意义(P<0.05);治疗后,联合组的hs-CRP、RF、ESR、IL-17、TL1A显著低于对照组,差异均有统计学意义(P<0.05)。结论:桂枝附子汤联合西医常规疗法能改善类风湿性关节炎患者的临床症状,减轻炎症反应。

    Abstract:

    Objective: To observe the clinical effect of Guizhi Fuzi tang combined with routine western therapy for rheumatoid arthritis.Methods:Divided 96 patients with rheumatoid arthritis into the combination group and the control group randomly,48 cases in each group.Both groups receivedroutine western therapy for treatment,while the combination group additionally received Guizhi Fuzi tang.Changes of main symptoms including swollen joint count,pain joint count and time of morning stiffness of patients in both groups were compared.Pain degrees of patients were evaluated by visual analogue scale(VAS).Changes of illness of patients were evaluated by rheumatoid arthritis disease activity score(DAS28).Levels of hypersensitive C-reactive protein(hs-CRP), rheumatoid factor(RF), erythrocyte sedimentation rate(ESR), interleukin 17(IL-17),and tumor necrosis factor related ligand 1A(TL1A)before and after treatment were detected in both groups.Results:Compared the clinical effect between the two groups,the difference being significant(P < 0.05),and the curative effect of the combination group was better than that of the control group.Swollen joint count, pain joint count, time of morning stiffness, VAS scores and DAS28 scores after treatment in both groups were significantly lower than before treatment,differences being significant(P < 0.05).After treatment,swollen joint count,pain joint count,time of morning stiffness,VAS scores and DAS28 scores in the combination group were lower than those in the control group,differences being significant(P< 0.05).Levels of hs-CRP,RF,ESR,IL-17 and TL1A after treatment in both groups were significantly lower than those before treatment,differences being significant(P < 0.05).After treatment,levels of hs-CRP,RF,ESR,IL-17 and TL1A in the combination group were significantly lower than those in the control group,differences being significant(P<0.05).Conclusion:The therapy of Guizhi Fuzi tang combined with routine western therapy can improve clinical symptoms of patients with rheumatoid arthritis and relieve inflammation.

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胡根清.桂枝附子汤联合西医常规疗法治疗类风湿关节炎临床观察[J].新中医,2017,49(12):72-75

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  • 在线发布日期: 2017-12-02
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