温州地区103例卵巢早衰患者中医体质类型调查及中医体质与性激素水平的相关性研究
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R711.75

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温州市科技局公益性社会发展(医疗卫生)科技项目(Y20160218)


Investigation on Chinese Medicine Constitution Types and Study on Correlation of Chinese Medicine Constitution with Sex Hormone Levels in Patients with Premature Ovarian Failure:A Study of 103 Cases in Wenzhou
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    摘要:

    目的:观察温州市103例卵巢早衰 (POF)患者的中医体质类型分布规律,比较不同中医体质类型POF患者的性激素水平。方法:对符合诊断标准的103例POF患者进行中医体质辨识,统计各中医体质类型例数及比例,记录不同中医体质类型POF患者促卵泡刺激素(FSH)、促黄体生成素(LH)及雌二醇(E2)水平,并进行比较。结果:103例POF患者以偏颇体质为主,共95例,占92.23%。阴虚质(29.13%) >气郁质(19.42%) >气虚质(15.53%) >阳虚质(14.56%) >湿热质(6.80%) >痰湿质(3.88%)>血瘀质(2.91%)。阴虚质组、气郁质组、阳虚质组及气虚质组的E2、FSH及LH水平经单因素方差分析,差异均有统计学意义(P<0.05)。4种不同体质类型POF患者E2水平两两比较,气虚质>阳虚质>气郁质>阴虚质(P<0.05)。4种不同体质类型POF患者LH水平两两比较,阴虚质>气郁质(P<0.05),阴虚质>气虚质(P<0.05);阴虚质与阳虚质、气郁质与阳虚质、气郁质与气虚质、阳虚质与气虚质的LH水平比较,差异均无统计学意义(P>0.05)。4种不同体质类型POF患者FSH水平两两比较,阴虚质>气郁质(P<0.05),阴虚质>阳虚质(P<0.05),阴虚质>气虚质(P<0.05),气郁质>阳虚质(P<0.05);气郁质与气虚质、阳虚质与气虚质POF患者FSH水平比较,差异均无统计学意义(P>0.05)。结论:温州市103例POF患者中医体质类型以阴虚质为主,其次为气郁质、气虚质及阳虚质。阴虚体质患者的E2水平下降程度及FSH水平的上升程度较气郁质、阳虚质及气虚质更为明显。

    Abstract:

    Objective:To observe the distribution law of Chinese medicine(CM)constitution types among 103 cases of premature ovarian failure patients in Wenzhou,and to compare the sex hormone level in different CM constitution type.Methods:Identified the CM constitution types of 103 cases of premature ovarian failure patients,and counted the cases number as well as the proportion of each CM constitution type.Recorded and compared levels of follicle stimulating hormone(FSH),luteinizing hormone(LH)and estrogen(E2)in premature ovarian failure patients with different CM constitution types.Results: Among 103 cases of premature ovarian failure patients, 95 cases had abnormal constitution, accounting for 92.23%.The proportions of other constitution types were as follow:yin-deficiency constitution(29.13%)>qi-stagnation constitution(19.42%)>qi-deficiency constitution(15.53%)>yang-deficiency constitution(14.56%)>dampness-heat constitution(6.80%)> phlegm-dampness constitution(3.88%)>blood stasis constitution(2.91%).Levels of E2,FSH and LH in patients with yin-deficiency constitution, qi-stagnation constitution, yang-deficiency constitution, and qi-deficiency constitution were analyzed by one-way ANOVA,differences being significant(P<0.05).Comparing E2levels in patients with four constitution types,it was found that qi-deficiency constitution>yang-deficiency constitution>qi-stagnation constitution>yin-deficiency constitution(P<0.05).Comparing LH levels in patients with four constitution types, the results wereyin-deficiency constitution>qi-stagnation constitution(P<0.05)and yin-deficiency constitution>qi-deficiency constitution(P<0.05).There was no significant difference being found in the comparisons of LH levels between yin-deficiency constitution and yang-deficiency constitution,qi-stagnation constitution and yang-deficiency constitution,qi-stagnation constitution and qi-deficiency constitution,and between yang-deficiency constitution and qi-deficiency constitution(P>0.05).Comparison of FSH levels in patients with four constitution types showed that yin-deficiency constitution>qi-stagnation constitution(P<0.05), yin-deficiency constitution>yang-deficiency constitution (P<0.05), yin-deficiency constitution>qi-deficiency constitution(P<0.05),and qi-stagnation constitution>yang-deficiency constitution(P<0.05).There was no significant difference in the comparison of FSH levels between qi-stagnation constitution and qi-deficiency constitution,and between yang-deficiency constitution and qi-deficiency constitution(P>0.05).Conclusion:CM constitution types among 103 cases of premature ovarian failure patients in Wenzhou are mainly yin-deficiency constitution,followed by qi-stagnation constitution,qi-deficiency constitution and yang-deficiency constitution.The decrease of E2levels and increase of FSH levels in patients with yin-deficiency constitution are more obvious than those in patients with qi-stagnation constitution,yang-deficiency constitution and qi-deficiency constitution.

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林希,徐苗苗,周毅,林祥,朱雪琼,米海霞,胡洁菡.温州地区103例卵巢早衰患者中医体质类型调查及中医体质与性激素水平的相关性研究[J].新中医,2017,49(12):92-94

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  • 在线发布日期: 2017-12-02
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