安神定志方联合西药治疗高血压病伴原发性失眠临床观察
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R544.1; R256.23

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Clinical Observation of Anshen Dingzhi Prescription Combined with Western Medicine for Hypertension with Primary Insomnia
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    摘要:

    目的:观察安神定志方联合西药治疗高血压病伴原发性失眠的临床疗效。方法:将108例高血压病伴原发性失眠的患者随机分为2组,对照组采用降压药治疗,观察组在降压药物治疗的基础上给予安神定志方治疗,2组疗程均为1月。疗程结束后对2组的睡眠改善情况进行评价,并观察治疗前后匹兹堡睡眠质量量表(PSQI)评分、血压、心肌功能指标[血清心肌肌钙蛋白T(cTnT)、心室直径变化速率(dD/dt)]的变化,统计2组治疗结束后3月的心血管事件发生情况。结果:治疗后,观察组睡眠改善情况优于对照组(P<0.05)。2组PSQI评分、收缩压、舒张压、cTnT和dD/dt均较治疗前下降(P<0.05,P<0.01),观察组PSQI评分、收缩压、舒张压、cTnT和dD/dt均低于对照组(P<0.05,P<0.01)。治疗后3月,观察组的心血管事件发生率低于对照组(P<0.05)。结论:安神定志方联合西药治疗高血压病伴原发性失眠患者有助于改善睡眠、控制血压,改善心肌功能,降低治疗后的心血管事件发生率。

    Abstract:

    Objective:To observe the clinical effect of Anshen Dingzhi prescription combined with western medicine for hypertension with primary insomnia.Methods:Divided 108 cases of patients of hypertension with primary insomnia into the control group and the observation group randomly.Both groups receivedhypotensor for treatment,while the observation group additionally received Anshen Dingzhi prescription.The course of treatment for both groups lasted for a month.After treatment, evaluated improvement of sleep, observed changes of scores of pittsburgh sleep quality index(PSQI), blood pressure as well as myocardial function indexes including serum cardiac troponin T(cTnT)and delta diameter/delta time(dD/dt)before and after treatment.Cardiovascular events in both groups were collected 3 months after treatment.Results:After treatment,improvement of sleep in the observation group was better than that in the control group(P< 0.05).PSQI scores,systolic pressure,diastolic pressure,and levels of cTnT and dD/dt in both groups were lower than those before treatment(P< 0.05,P< 0.01).PSQI scores,systolic pressure,diastolic pressure,and levels of cTnT and dD/dt in the observation group were lower than those in the control group(P<0.05,P< 0.01).Three months after treatment,the incidence of cardiovascular events in the observation group was lower than that of the control group(P<0.05).Conclusion:Anshen Dingzhi prescription combined with western medicine for hypertension with primary insomnia can improve sleep,control blood pressure,enhance myocardial function and decrease the incidence of cardiovascular events after treatment.

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张佳凤.安神定志方联合西药治疗高血压病伴原发性失眠临床观察[J].新中医,2018,50(1):26-29

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  • 在线发布日期: 2018-01-05
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