慢性阻塞性肺疾病患者中医证型与凝血、纤溶指标的相关性研究
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ResearchonCorrelationofChineseMedicineSyndromewithCoagulationand Fibrinolysis Indexes of Patients with Chronic Obstructive Pulmonary Disease
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    摘要:

    目的:分析慢性阻塞性肺疾病患者中医证型与凝血、纤溶指标的相关性。方法:将150例慢性阻塞性肺疾病患者依照中医证型不同分为痰热壅肺组、肺脾两虚组、肺肾两虚组各50例,同期选取50例健康人设为对照组。检测血中D-二聚体(DD)、活化部分凝血活酶时间(aPTT)、凝血酶原时间(PT)、纤维蛋白原(Fbg),并对患者的肺功能分级进行评估。结果:痰热壅肺组肺功能最优,肺脾两虚组肺功能最差。3组患者的肺功能情况存在统计学差异(P<0.01)。病例组PT、aPTT水平均低于对照组(P<0.01),Fbg、D-D水平均高于对照组(P<0.01)。痰热壅肺组PT、aPTT水平均高于肺肾两虚组及肺脾两虚组(P<0.05),Fbg、D-D水平均低于肺肾两虚组及肺脾两虚组(P<0.05)。肺肾两虚组PT、aPTT水平高于肺脾两虚组(P<0.05),Fbg、D-D水平均低于肺脾两虚组(P<0.05)。PT、aPTT与痰热壅肺、肺肾两虚、肺脾两虚证型呈负相关(P<0.01),Fbg、D-D水平与痰热壅肺、肺肾两虚、肺脾两虚证型呈正相关(P<0.05,P<0.01)。结论:慢性阻塞性肺疾病患者的中医证型与凝血、纤溶指标显著相关,凝血、纤溶指标可作为推测慢性阻塞性肺疾病患者中医证型的辅助指标。

    Abstract:

    Objective:To analyze correlation of Chinese medicine syndrome with coagulation and fibrinolysis indexes of patients with chronic obstructive pulmonary disease.Methods:According to the difference of Chinese medicine syndrome,divided 150 patients with chronic obstructive pulmonary disease into phlegm-heat obstructing lung group,lung and spleen deficiency group as well as lung and kidney deficiency group,50 cases in each group.50 healthy people were selected as the control group in the meanwhile.Detected levelsof D-Dimer in blood, activated partial thromboplastin time(aPTT),prothrombin time(PT)and fibrinogen(Fbg)and evaluated pulmonary function grade of patients.Results:Pulmonary function of phlegm-heat obstructing lung group was the best in the three groups,while pulmonary function of lung and spleen deficiency group was the worst.The comparisons of pulmonary function of patients among the three groups showed differences(P<0.01).Levels of PT,aPTT in the case group were lower than those in the control group(P<0.01).Levels of Fbg and D-D in the case group were higher than those in the control group(P<0.01).Levels of PT,aPTT in phlegm-heat obstructing lung group were higher than those in lung and kidney deficiency group and lung and spleen deficiency group(P<0.05).Levels of Fbg and D-D in phlegm-heat obstructing lung group were lower than those in lung and kidney deficiency group and lung and spleen deficiency group(P<0.05).Levels of PT,aPTT in lung and kidney deficiency group were higher than those in lung and spleen deficiency group(P<0.05).Levels of Fbg and D-D in lung and kidney deficiency group were lower than those in lung and spleen deficiency group(P<0.05).There was a negative correlation between PT,aPTT and phlegm-heat obstructing lung,lung and kidney deficiency,and lung and spleen deficiency syndromes types(P<0.01).There was a positive correlation between levelsof Fbg,D-D and phlegm-heat obstructing lung,lung and kidney deficiency,and lung and spleen deficiency syndromes types(P<0.05,P<0.01).Conclusion:There is a significant correlation of Chinese medicine syndrome with coagulation and fibrinolysis indexes ofpatients with chronic obstructive pulmonary disease.Coagulation andfibrinolysis indexes can be auxiliary indexes to speculate Chinese medicine syndrome of patients with chronic obstructive pulmonary disease.

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薛河东.慢性阻塞性肺疾病患者中医证型与凝血、纤溶指标的相关性研究[J].新中医,2018,50(1):38-40

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  • 在线发布日期: 2018-01-05
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