麝香保心丸治疗冠心病稳定型心绞痛疗效观察及对血清ROS、CT-1的调节作用
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R541.4

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Observation of Shexiang Baoxin Pills for Stable Angina Pectoris of Coronary Heart Disease and Its Regulating Effect on ROS and CT-1 in Serum
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    摘要:

    目的:观察麝香保心丸联合西医措施对冠心病稳定型心绞痛(SAP)气滞血瘀证的疗效,以及对血清活性氧物质(ROS)和心肌营养素-1(CT-1) 水平的调节作用。方法:将SAP患者88例按照随机数字表法分为2组各44例。对照组参见指南予常规治疗措施。观察组在对照组基础上口服麝香保心丸。治疗12周后,比较2组气滞血瘀证症状评分、心绞痛的发作、临床疗效、血清ROS和CT-1水平。结果:治疗后,2组气滞血瘀证症状评分减少(P<0.01),且观察组气滞血瘀证症状评分低于对照组(P<0.01)。治疗后,2组每周心绞痛发作次数、每次心绞痛持续时间减少(P<0.01),且观察组每周心绞痛发作次数、心绞痛持续时间低于对照组(P<0.01)。观察组总有效率为95.35%,对照组为77.27%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清ROS、CT-1水平降低,且观察组血清ROS、CT-1低于对照组(P<0.01)。结论:麝香保心丸联合西医措施治疗SAP气滞血瘀证疗效显著,其疗效可能与下调ROS和CT-1水平有关。

    Abstract:

    To observe the curative effect of Shexiang Baoxin pills combined with measures of western medicine for stable angina pectoris(SAP)of coronary heart disease with blood stasis due to qi stagnation syndrome,and its regulating effect on the levels of reactive oxygen species(ROS)and cardiotrophin-1(CT-1)in serum.Methods:A total of 88 cases of SAP patients were divided into two groups according to the random number table method,44 cases in each group.The control group was given routine treatment according to the guidelines,and the observation group was additionally given oral administration of Shexiang Baoxin pills based on the treatment of the control group.After treatment for 12 weeks,the symptom scores of blood stasis due to qi stagnation syndrome,the angina pectoris attacks,the clinical effect and the levels of ROS and CT-1 in serum in the two groups were compared.Results:After treatment,the symptom scores of blood stasis due to qi stagnation syndrome in the two groups were decreased(P < 0.01),and the score in the observation group was lower than that in the control group(P < 0.01).After treatment,the frequency of angina pectoris attacks per week and the duration of each attack in the two groups were decreased(P < 0.01),and the above two indexes in the observation group were less than those in the control group(P<0.01).The total effective rate was 95.35%in the observation group and 77.27%in the control group,the difference being significant(P < 0.05).After treatment,the levels of ROS and CT-1 in serum in the two groups were decreased,and the levels in the observation group were lower than those in the control group(P<0.01).Conclusion:The therapy of Shexiang Baoxin pills combined with measures of western medicine in treating SAP with blood stasis due to qi stagnation syndrome has significant curative effect,whose curative effect may be related to the downregulation of the levels of ROS and CT-1.

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陈秀珍,陈冲.麝香保心丸治疗冠心病稳定型心绞痛疗效观察及对血清ROS、CT-1的调节作用[J].新中医,2019,51(10):87-89

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  • 在线发布日期: 2019-10-11
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