补骨颗粒对中老年股骨颈骨折空心钉固定术后骨量的影响
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R683

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福建省自然科学基金资助项目(2016J01597);福州市科技计划项目(2017-S-130-5)


A Study on Effect of Bugu Granules on Bone Mass after Hollow Screw Fixation of the Middle-aged and Elderly People with Femoral Neck Fracture
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    摘要:

    目的:观察补骨颗粒对中老年股骨颈骨折患者空心钉固定术后骨量的影响,为临床防治废用性骨质疏松提供依据。方法:将行空心钉内固定治疗的股骨颈骨折患者58例,随机分为2组各29例,对照组行空心钉内固定术后给予碳酸钙D3片口服,实验组在对照组的基础上加用补骨颗粒口服,2组疗程均为3个月,观察比较2组治疗前后骨量及相关生化指标的变化。结果:治疗后,2组骨密度值仍明显低于治疗前(P<0.05),且对照组骨密度低于实验组(P<0.05)。治疗后,实验组骨矿含量较治疗前低,但差异无统计学意义(P>0.05);与对照组治疗后比较,差异亦无统计学意义(P>0.05)。治疗后,对照组骨矿含量较治疗前明显降低(P<0.05)。术后3个月,实验组血钙水平高于术后3天、术后1个月,差异均有统计学意义(P<0.05);对照组各个时间段血钙水平组间两两比较,差异均无统计学意义(P>0.05)。术后1个月、术后3个月,实验组肌酐水平较术后3天明显升高(P<0.05),且高于对照组相同时间段的肌酐水平(P<0.05);但其术后1个月与术后3个月的肌酐水平差异不大(P>0.05)。对照组各个时间段肌酐水平组间两两比较,差异均无统计学意义(P>0.05)。2组不良反应轻微,经对症处理后均不影响治疗。结论:补骨颗粒预防股骨颈骨折术后骨质疏松安全有效,其疗效机制可能是通过调控生物化学信号而影响骨小梁,但确切机制仍需进一步的研究。

    Abstract:

    To observe the effect of Bugu granules on bone mass after hollow screw fixation of the middle-aged and elderly patients with femoral neck fracture,so as to provide basis for clinical prevention and treatment of disuse osteoporosis.Methods:A total of 58 cases of patients with femoral neck fracture undergoing internal fixation with hollow screws were randomly divided into two groups,29 cases in each group.After internal fixation with hollow screws,the control group was given oral administration of calcium carbonate and vitamin D3 tablets,and the experiment group was additionally treated with oral administration of Bugu granules based on the treatment of the control group.Both groups were treated for three months.The changes in bone mass and biochemical indexes before and after treatment in the two groups were observed and compared.Results: After treatment, the bone mineral density values in the two groups were still significantly lower than those before treatment(P < 0.05),and the one in the control group was lower than that in the experiment group(P < 0.05).After treatment,the bone mineral content in the experiment group was decreased when compared with that before treatment,but there was no significance in the difference(P > 0.05);no significant difference was found in the comparison of the contents between the two groups(P > 0.05).After treatment,the bone mineral content in the control group was significantly decreased when compared with that before treatment(P<0.05).After surgery for three months,the level of blood calcium in the experiment group was higher than those after surgery for three days and for one month respectively,differences being significant(P < 0.05);compared each two levels in different time periods in the control group respectively,there was no significance in the difference(P > 0.05).After surgery for one month and for three months,the levels of creatinine in the experiment group were significantly increased when compared with that after surgery for three days respectively(P < 0.05),and were higher than those in the control group in the same period respectively(P < 0.05);compared the levels in the experiment group after surgery for one month and for three months,there was no significance in the difference(P>0.05).No significant difference was found in the comparison of each two levels of creatinine in the control group in different time periods respectively(P>0.05).The adverse reactions in the two groups were mild and did not affect the treatment after expectant treatment.Conclusion:Bugu granules is safe and effective to prevent osteoporosis after surgery for femoral neck fracture,whose therapeutic mechanism may be the effect on trabecula bone by regulating synthesis of biochemical signals,but the exact mechanism still needs further study.

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余光书,林焱斌,熊国胜.补骨颗粒对中老年股骨颈骨折空心钉固定术后骨量的影响[J].新中医,2019,51(10):165-168

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  • 在线发布日期: 2019-10-11
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