中药内服联合黄芪注射液穴位注射治疗胃食管反流病临床研究
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Clinical Study on Oral Administration of Chinese Medicine Combined with Point Injection of Radix Astragali Injection for Gastroesophageal Reflux Disease
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    摘要:

    目的:观察中药内服联合黄芪注射液穴位注射治疗胃食管反流病(GERD) 的临床疗效。方法:将124 例GERD 患者按随机数字表法分为研究组与对照组各62 例。对照组给予奥美拉唑肠溶胶囊联合枸橼酸莫沙必利片治疗,研究组在对照组基础上加用中药内服及黄芪注射液穴位注射治疗,2 组均连续治疗8 周。比较2 组临床疗效及治疗前后的中医证候积分、食管反流次数和反流时间,观察不良反应发生情况,停药2 个月后统计复发率。结果:研究组总有效率为96.77%,对照组总有效率为85.48%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组反酸、烧心、胸骨后灼痛、胸胁胀满、心烦易怒积分均较治疗前下降(P<0.05),研究组上述5 项中医证候积分均低于对照组(P<0.05)。治疗后,2 组24 h 反流总次数及反流持续时间≥5 min 次数均较治疗前减少(P<0.05),最长反流持续时间均较治疗前缩短(P<0.05);研究组24 h 反流总次数及反流持续时间≥5 min 次数均少于对照组(P<0.05),最长反流持续时间短于对照组(P<0.05)。治疗期间,2 组均未出现严重不良反应。研究组复发率为11.67%,对照组复发率为28.30%,2 组比较,差异有统计学意义(P<0.05)。结论:中药内服联合黄芪注射液穴位注射治疗GERD,可有效改善患者的临床症状,降低复发率,且无明显不良反应。

    Abstract:

    Abstract: Objective: To observe the clinical effect of oral administration of Chinese medicine combined with point injection of radix astragali injection for gastroesophageal reflux disease(GERD). Methods: A total of 124 cases of GERD patients were divided into the study group and the control group according to the random number table method,62 cases in each group. The control group was given omeprazole enteric capsules combined with mosapride citrate tablets,and the study group was additionally treated with oral administration of Chinese medicine and point injection of radix astragali injection based on the treatment of the control group. Both groups were continuously treated for eight weeks. Chinese medicine syndrome scores and the times and duration of gastroesophageal reflux before and after treatment,as well as the clinical effect were compared between the two groups. The incidence of adverse reactions was observed. After two- month medicine withdrawal,the recurrence rate was counted. Results:The total effective rate was 96.77% in the study group,better than that of 85.48% in the control group, the difference being significant(P<0.05). After treatment, the scores of acid regurgitation, heartburn, substernal burning sensation, fullness in the chest and hypochondrium as well as vexation and irascibility in the two groups were decreased when compared with those before treatment(P<0.05), and the above five scores in the study group were lower than those in the control group(P<0.05). After treatment,the total times of reflux in 24 hours and the times of the duration equal or longer than 5 minutes in the two groups were reduced when compared with those before treatment(P<0.05),and the longest duration of reflux was shorter(P<0.05). The total times of reflux in 24 hours and the times of the duration equal or longer than 5 minutes in the study group were less than those in the control group(P< 0.05),and the longest duration of reflux was shorter(P<0.05). During treatment,there was no significant adverse reaction or complication in the two groups. The recurrence rate was 11.67% in the study group and 28.30% in the control group,the difference being significant(P<0.05). Conclusion:The therapy of oral administration of Chinese medicine combined with point injection of radix astragali injection in treating GERD can effectively improve clinical symptoms and reduce recurrence rate, without significant adverse reaction.

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江瑞.中药内服联合黄芪注射液穴位注射治疗胃食管反流病临床研究[J].新中医,2020,52(17):71-74

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  • 在线发布日期: 2020-09-06
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