益气消瘤方联合化疗治疗大肠癌根治术后临床研究
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R735.3+4

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Clinical Study on Yiqi Xiaoliu Prescription Combined with Chemotherapy for Patients After Radical Surgery for Colorectal Cancer
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    摘要:

    目的:观察益气消瘤方联合化疗对大肠癌根治术后患者临床疗效、中医证候积分、免疫功能及不良反应的影响。方法:选取行择期保肛根治术治疗的86 例大肠癌患者,采用随机数字表法分为对照组和观察组各43 例。对照组给予奥沙利铂+5-氟尿嘧啶+亚叶酸钙(FOLFOX4) 化疗,观察组在对照组基础上予以益气消瘤方口服。比较2 组治疗前后中医证候积分、免疫功能[T 淋巴细胞亚群(CD3+、CD4+/CD8+)] 差异,并记录2 组临床疗效及化疗期间不良反应发生情况。结果:治疗后,2 组主症及次症中医证侯积分均较治疗前降低(P<0.05),且观察组主症及次症中医证侯积分均低于对照组(P<0.05)。治疗后,对照组CD3+、CD4+/CD8+水平与治疗前比较,差异无统计学意义(P>0.05);观察组CD3+、CD4+/CD8+水平则均较治疗前升高(P<0.05),且高于对照组(P<0.05)。观察组临床疗效明显优于对照组(P<0.05),观察组恶心呕吐、腹泻、贫血、血小板减少、粒细胞减少发生率均低于对照组(P<0.05)。结论:益气消瘤方联合化疗治疗大肠癌根治术后患者效果显著,可缓解患者中医证候,改善免疫功能,还能减轻不良反应,有利于患者预后。

    Abstract:

    Abstract: Objective: To observe the effect of Yiqi Xiaoliu prescription combined with chemotherapy on the clinical effect, Chinese medicine syndrome scores, immune function and adverse reactions in patients after radical surgery for colorectal cancer. Methods: A total of 86 cases of patients with colorectal cancer undergoing selective anus- preserving radical surgery were divided into the control group and the observation group according to the random number table method, 43 cases in each group. The control group was treated with FOLFOX4 chemotherapy which included oxaliplatin, 5- fluorouracil and calcium folinate, and the observation group was additionally treated with oral administration of Yiqi Xiaoliu prescription based on the treatment of the control group. The differences in Chinese medicine syndrome scores and the indexes related to immune function,namely CD3+ and CD4+/CD8+ in T lymphocyte subsets were compared between the two groups before and after treatment. The clinical effect and the incidence of adverse reactions during chemotherapy were recorded in the two groups. Results:After treatment,the Chinese medicine syndrome scores of the main and secondary symptoms in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05). After treatment,compared the levels of CD3 + and CD4+/CD8+ in the control group before and after treatment,there was no significance in the difference(P>0.05);the levels of CD3 + and CD4 +/CD8 + in the observation group were increased when compared with those before treatment(P<0.05),and higher than those in the control group(P<0.05). The clinical effect in the observation group was significantly better than that in the control group(P<0.05). The incidence of nausea,vomiting,diarrhea,anemia,thrombocytopenia and neutropenia was lower than that in the control group(P<0.05). Conclusion: The therapy of Yiqi Xiaoliu prescription combined with chemotherapy has significant curative effect in treating patients after radical surgery for colorectal cancer. It can relieve their Chinese medicine syndromes,improve the immune function and reduce adverse reactions,which is beneficial to prognosis.

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张寅刚,许吟枫.益气消瘤方联合化疗治疗大肠癌根治术后临床研究[J].新中医,2020,52(13):118-121

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  • 在线发布日期: 2020-07-10
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