补肾活血方联合低分子肝素治疗复发性流产伴子宫动脉血流异常临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R714.21

基金项目:


Clinical Study on Bushen Huoxue Prescription Combined with Low Molecular Weight Heparin for Recurrent Spontaneous Abortion Complicated with Abnormal Uterine Artery Blood Flow
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察补肾活血方联合低分子肝素治疗复发性流产伴子宫动脉血流异常的临床疗效。方法:选取子宫动脉血流阻力异常的复发性流产患者 72 例,按随机数字表法分为观察组和对照组,各 36 例。对照组给予低分子肝素治疗,观察组在对照组的基础上加用补肾活血方治疗。比较 2 组临床疗效、中医证候积分、子宫动脉阻力指数(RI)、收缩期峰值流速/舒张末期流速(S/D),血清绒毛膜促性腺激素(β-HCG)、雌二醇(E2)、孕酮(P)水平,以及孕 12 周保胎成功率。结果:观察组总有效率为86.11%,对照组为 69.44%,2 组比较,差异有统计学意义 (P<0.05)。治疗后,2 组中医证候积分均较治疗前下降 (P<0.05),且观察组积分显著低于对照组 (P<0.05)。2 组左、右侧 RI、S/D 水平均较治疗前显著下降 (P<0.05),且观察组 2 项指标均低于对照组(P<0.05)。治疗后,2 组血清 β-HCG、P、E2水平均较治疗前升高(P<0.05),且观察组血清 β-HCG、P 水平高于对照组 (P<0.05),E2水平与对照组比较相差不大 (P>0.05)。治疗后,观察组孕 12 周保胎成功率、再次流产率分别为 88.89%、11.11%,对照组分别为 72.22%、27.78%,2 组比较,差异有统计学意义 (P<0.05)。结论:补肾活血方联合低分子肝素能有效降低复发性流产患者的子宫动脉血流阻力,改善母胎间血液循环,有助于维持妊娠的正常进行。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Bushen Huoxue prescription combined with low molecular weight heparin on recurrent spontaneous abortion complicated with abnormal uterine artery blood flow. Methods: A total of 72 patients with recurrent spontaneous abortion complicated with increased uterine artery blood flow resistance were selected and divided into the observation group and the control group according to the random number table method, 36 cases in each group. The control group was treated with low molecular weight heparin,and the observation group was additionally treated with Bushen Huoxue prescription based on the treatment of the control group. The clinical effect,Chinese medicine syndrome scores , resistance index of uterine artery(RI) , peak systolic velocity/end diastolic(S/D) , levels of β -human chorionic gonadotropin in serum(β-HCG),estradiol(E2) and progesterone(P),and success rate of fetal protection at 12 weeks were compared between the two groups. Results:The total effective rate was 86.11% in the observation group and 69.44% in the control group,the difference being significant(P<0.05). After treatment,the Chinese medicine syndrome scores in both groups were decreased when compared with those before treatment(P<0.05), and the scores in the observation group were lower than those in the control group(P<0.05). The left RI and right RI and S/D levels in both groups were significantly decreased when compared with those before treatment(P<0.05), and the above two levels in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of β-HCG,P and E2 in serum in the two groups were increased when compared with those before treatment(P<0.05),and the levels of β-HCG and P in serum in the observation group were higher than those in the control group(P<0.05), while the E2 level was not significantly correlated with the control group(P>0.05). After treatment,the success rate of fetal protection at 12 weeks and the rate of repeat abortion were 88.89% and 11.11% in the observation group,and 72.22% and 27.78% in the control group, respectively,the difference being significant(P<0.05). Conclusion:The therapy of Bushen Huoxue prescription combined with low molecular weight heparin can effectively reduce the uterine artery blood flow resistance in patients with recurrent spontaneous abortion,improve the blood circulation between mother and fetus,and help to maintain the normal pregnancy.

    参考文献
    相似文献
    引证文献
引用本文

孔德佳,黄飞翔,徐峻苗.补肾活血方联合低分子肝素治疗复发性流产伴子宫动脉血流异常临床研究[J].新中医,2021,53(1):85-89

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2021-01-11
  • 出版日期: