胰肾康丸对胰岛素抵抗大鼠空腹血糖和胰岛素的影响
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R578

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湖北省自然科学基金面上项目(2015CFC830)


Yishenkang Pills Can Downregulate Fasting Blood Glucose and Insulin in Rats with Insulin Resistance
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    摘要:

    目的:研究胰肾康丸对胰岛素抵抗大鼠空腹血糖和空腹胰岛素含量的影响。方法:60只SD雄性大鼠,随机取10只设为空白组饲以基础饲料,余50只饲以高脂高糖饲料联合腹腔注射链脲佐菌素(STZ)以构建胰岛素抵抗模型,并于8周后选取造模成功的大鼠随机分为模型组、胰肾康丸高、中、低剂量组和二甲双胍组,胰肾康丸低、中、高剂量组分别给予胰肾康丸悬液150 mg/(kg·d)、300 mg/(kg·d)、600 mg/(kg·d)灌胃,二甲双胍组给予二甲双胍悬液250 mg/(kg·d)灌胃,模型组灌胃等量生理盐水,持续给药4周。测定治疗前后各组大鼠空腹血糖(FBG)和空腹胰岛素(FINS)水平。结果:与空白组比较,造模组大鼠体质量、FBG和FINS水平显著升高,差异均有统计学意义(P<0.05),说明模型成立。药物处理4周后,与治疗前比较,胰肾康丸中、高剂量组和二甲双胍组大鼠FBG、FINS水平显著降低,胰肾康丸低剂量组大鼠FINS水平显著降低,差异均有统计学意义(P<0.05)。治疗后,与模型组比较,胰肾康丸低、中、高剂量组和二甲双胍组大鼠FBG、FINS水平显著降低,差异均有统计学意义(P<0.05)。与二甲双胍组比较,胰肾康丸低剂量组大鼠FBG、FINS水平较高(P<0.05),胰肾康丸高、中剂量组大鼠无显著差异(P>0.05)。结论:胰肾康丸能显著降低胰岛素抵抗大鼠空腹血糖和空腹胰岛素的水平,对2型糖尿病胰岛素抵抗有一定疗效。

    Abstract:

    Objectives:To study the effect of Yishenkang pills on the content of fasting blood glucose and fasting insulin in rats with insulin resistance.Methods:Among 60 SD male rats,10 rats were given the basic feed randomly as the blank group,50 rats were fed with high fat and high carbohydrate diet combined with intraperitoneal injection of streptozotocin(STZ)to establish insulin resistance model.After eight weeks,divided successful modeling rats randomly into model group,Yishenkang pill high dose group,Yishenkang pill medium dose group,Yishenkang pill low dose group,and metform group.Yishenkang pill high,medium,low dose groups were respectively given 150 mg/(kg·d),300 mg/(kg·d)and 600 mg/(kg·d)of Yishenkang suspension by gavage.Metform group was given 250 mg/(kg·d)of metform suspension by gavage.The model group was given equivalent dose of normal saline by gavage.All groups continued medication for 4 weeks.Determined levels of fasting blood glucose(FBG)and fasting insulin(FINS)in these groups before and after medication.Results:In comparison with the blank group, body mass as well as levels of FBG and FINS in the model group were remarkably increased,differences being significant(P < 0.05),which indicated that the model was valid.After four weeks of medication,in comparison to those before treatment,levels of FBG and FINS in Yishenkang pill medium and high dose groups as well as metform group were remarkably decreased,while FINS levels in Yishenkang pill low dose group were remarkably decreased(P< 0.05).After medication,in comparison to the model group,levels of FBG and FINS in Yishenkang pill high,medium,low dose group and metform group were remarkably decreased(P<0.05).In comparison to metform group,levels of FBG and FINS in Yishenkang pill low dose group were higher(P< 0.05),while levels of FBG and FINS in Yishenkang pill high dose group and medium dose group showed no significant difference(P>0.05).Conclusion:Yishenkang pills can significantly decrease the level of insulin resistance to FBG and FINS,having a certain curative effect on insulin resistance of type 2 diabetes.

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段正富,陈明达,王紫阳.胰肾康丸对胰岛素抵抗大鼠空腹血糖和胰岛素的影响[J].新中医,2017,49(12):1-3

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  • 在线发布日期: 2017-12-02
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