化积健脾方联合低热量肠内营养支持对原发性肝癌肝动脉栓塞化疗术后患者营养状况和细胞免疫功能的影响
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R730.59

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Effect of Huaji Jianpi Prescription Combined with Hypocaloric Enteral Nutrition Support on Nutritional Status and Cellular Immunity of Patients with Primary Hepatic Cancer After Transcatheter Hepatic Arterial Chemoembolization
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    摘要:

    目的:观察化积健脾方联合低热量肠内营养支持对原发性肝癌肝动脉栓塞化疗(TACE)术后患者营养状况和细胞免疫功能的影响。方法:将80例原发性肝癌(肝郁脾虚、瘀血阻滞型)行TACE的患者随机分为2组各40例。对照组术后采用低热量肠内营养支持治疗,观察组在对照组治疗方案的基础上联合化积健脾方口服治疗,治疗4周为1疗程。比较2组治疗前后免疫功能T淋巴细胞CD4+、CD3+、CD4+/CD8+改善情况,比较2组血红蛋白(Hb)、白蛋白(Alb)、血清总蛋白(TP) 等营养指标改善的情况,比较2组临床疗效及并发症发生的情况。结果:治疗后,观察组各项免疫指标T淋巴细胞CD4+、CD3+、CD4+/CD8+,各项营养指标Hb、Alb、TP均升高,且高于对照组,差异均有统计学意义(P<0.05)。临床疗效总有效率对照组70.0%,观察组90.0%,2组比较,差异有统计学意义(P<0.05)。并发症总发生率对照组25.0%,观察组7.5%,2组比较,差异有统计学意义(P<0.05)。结论:化积健脾方联合低热量肠内营养支持治疗原发性肝癌TACE术后患者疗效显著,可更好地改善营养状态及免疫功能,并降低并发症发生率。

    Abstract:

    Objective:To observe the effect of Huaji Jianpi prescription combined with hypocaloric enteral nutrition support on nutritional status and cellular immunity of patients with primary hepatic cancer after receiving transcatheter hepatic arterial chemoembolization(TACE).Methods:Divided 80 cases of patients with primary hepatic cancer(liver-stagnation and spleen-deficiency type as well as accumulation of blood stasis type)after the treatment of TACE into two groups,40 cases in each group.Both groups receivedhypocaloric enteral nutrition support after the operation,while the observation group was additionally treated with Huaji Jianpi prescription for four weeks as a course.Compared the improvements of the immune function of T lymphocytes CD4+,CD3+and CD4+/CD8+before and after treatment,as well as the improvements of nutritional indexes such as hemoglobin(Hb),albumin(Alb)and serum total protein(TP).Compared the clinical effect and complications between the two groups.Results:After treatment,immune indexes of T lymphocytes CD4+,CD3+and CD4+/CD8+as well as nutritional indexes such as Hb,TP and Alb in the observation group were all increased and were all being higher than those in the control group,differences being significant(P<0.05).The total effective rate was 70.0%in the control group and 90.0%in the observation group,the difference being significant in the intergroup comparison(P<0.05).The total incidence rate of complication was 25.0%in the control group and 7.5%in the observation group,the difference being significant(P<0.05).Conclusion:The therapy of Huaji Jianpi prescription combined with hypocaloric enteral nutrition support for primary hepatic cancer after the treatment of TACE has remarkable clinical effect.It can evidently improve the nutritional status and immunity as well as decline the incidence rate of complication.

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陈金标,王文成.化积健脾方联合低热量肠内营养支持对原发性肝癌肝动脉栓塞化疗术后患者营养状况和细胞免疫功能的影响[J].新中医,2017,49(12):129-132

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  • 在线发布日期: 2017-12-02
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