益气滋阴活血方治疗早期糖尿病肾病临床观察
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R587.12

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Clinical Observation of Yiqi Ziyin Huoxue Prescription for Early Diabetic Nephropathy
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    摘要:

    目的:观察益气滋阴活血方内服对早期糖尿病肾病(DN)患者血糖、肾功能及血浆胱抑素C(CysC)、超敏C-反应蛋白(hs-CRP)的影响。方法:将80例早期DN患者随机分为治疗组和对照组各40例。2组均予糖尿病饮食、合理运动、口服降糖药或胰岛素控制血糖,对照组在此基础上口服替米沙坦片,治疗组在对照组治疗基础上加服益气滋阴活血方。观察2组治疗前后的中医症状评分、血糖、肾功能、CysC及hs-CRP的变化。结果:治疗后,2组中医症状评分均较治疗前降低(P<0.05);治疗组的中医症状评分比对照组下降更明显(P<0.05)。治疗后,2组空腹血糖(FBG)及餐后2 h血糖(P2hBG)、尿微量白蛋白(umAlb)、血肌酐(SCr)水平及尿白蛋白排泄率(UAER)均较治疗前降低(P<0.05);治疗组FBG、P2hBG、umAlb、SCr水平及UAER均比对照组下降更明显(P<0.05)。治疗后,2组CysC水平及治疗组的hs-CRP水平均较治疗前下降(P<0.05);治疗组的CysC及hs-CRP水平均低于对照组(P<0.05)。对照组治疗前后的hs-CRP水平比较,差异无统计学意义(P>0.05)。结论:益气滋阴活血方治疗早期DN,能有效改善患者的临床症状和肾功能,控制血糖,减轻炎症。

    Abstract:

    Objective:To observe the effect of oral administration of Yiqi Ziyin Huoxue prescription on blood glucose,renal function, plasma Cystatin C(CysC), and high sensitivity C-reactiveprotein(hs-CRP)in patientswith early diabetic nephropathy(DN).Methods:Selected 80 cases of patients with early DN,and divided them randomly into the treatment group and the control group, 40 cases in each group.Both groups were given diabetes diet, proper exercise, oral administration of hypoglycemic agents or insulin to control blood glucose.The control group was additionally given telmisartan tablets based on the mutual treatment,while the treatment group was additionally given Yiqi Ziyin Huoxue prescription based on the treatment of the control group.Observed changes of Chinese medicine symptom score, blood glucose, renal function, CysC and hs-CRP in both groups before and after treatment.Results: After treatment, Chinese medicine symptom scores of both groups were decreased when compared with those before treatment(P< 0.05),and the scores of the treatment group were decreased more obviously than those of the control group(P< 0.05).After treatment,levels of fasting blood-glucose(FBG), postprandial 2h plasma glucose(P2hBG), urinary microalbumin(umAlb), and serum creatinine(SCr)and urinary albumin excretion rate(UAER)in both groups were all decreased when compared with those before treatment(P<0.05).Levels of FBG,P2hBG,umAlb,and SCr as well as UAER of the treatment group were decreased more obviously than those of the control group(P< 0.05).After treatment,CysC levels in both groups and hs-CRP levels in the treatment group were both decreased when compared with those before treatment(P< 0.05),and levels of CysC and hs-CRP in the treatment group were lower than those in the control group(P<0.05).There was no significant difference being found in the comparison of hs-CRP levels in the control group before and after treatment(P>0.05).Conclusion:Yiqi Ziyin Huoxue prescription has a curative effect on early DN,which can effectively improve clinical symptoms and renal function,control blood glucose,and reduce inflammation of patients.

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周笑漪.益气滋阴活血方治疗早期糖尿病肾病临床观察[J].新中医,2018,50(1):60-63

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  • 在线发布日期: 2018-01-05
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