喜炎平注射液治疗轮状病毒肠炎临床观察
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R512.5

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广东省建设中医药强省立项资助科研课题(20131228)


Clinical Observation of Xiyanping Injection for Rotavirus Enteritis
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    摘要:

    目的:观察喜炎平注射液治疗轮状病毒肠炎的临床疗效和安全性。方法:选取180例轮状病毒肠炎患儿,随机分为对照组和治疗组各90例。对照组给予纠正水电解质酸碱平衡、补液等常规治疗,治疗组在对照组治疗基础上加喜炎平注射液。评估2组治疗效果,记录症状体征的缓解时间,观察治疗前后肌酸激酶(CK)、免疫功能指标(IgA、IgG)、谷丙转氨酶(ALT)、肌酐(SCr)的变化,记录不良反应发生情况。结果:对照组总有效率75.6%,治疗组总有效率91.1%,2组比较,差异有统计学意义(P<0.01)。治疗组发热、呕吐、腹泻、腹胀腹痛、脱水、病毒转阴时间及住院天数均短于对照组(P<0.05)。治疗后,2组CK水平均较治疗前降低(P<0.05),IgA、IgG水平均较治疗前升高(P<0.05);治疗组CK水平低于对照组(P<0.05),IgA、IgG水平均高于对照组(P<0.05)。治疗前后2组ALT及SCr水平组内及组间比较,差异均无统计学意义(P>0.05)。结论:在常规治疗基础上加用喜炎平注射液,能提高轮状病毒肠炎的治疗效果,增强患儿的免疫功能,缩短住院时间,服药期间无明显不良反应。

    Abstract:

    ObjectiveTo observe the clinical effect and safety of Xiyanping injection for rotavirus enteritis.MethodsSelected 180 cases of patients with rotavirus enteritis,and divided them randomly into the control group and the treatment group,90 cases in each group.The control group was given the treatment of correcting the balance of water-electrdyte and acid-base,fluid infusion and other conventional treatment,while the treatment group was given Xiyanping injection based on the treatment of the control group.Evaluated the curative effect of the two groups and recorded the relief time of symptoms and signs.Observed the changes of creatine kinase(CK),immune function index(IgA,IgG),alanine aminotransferase(ALT)and serum creatinine(SCr)before and after treatment,and then recorded the incidence of adverse reaction.ResultsThe total effective rate was 75.6%in the control group and was 91.1%in the treatment group,the difference being significant(P<0.01).The time of fever,vomiting,diarrhea,abdominal distention and pain,dehydration,and virus clearance time as well as hospitalization days in the treatment group were all shorter than those in the control group,differences being significant(P < 0.05).After treatment,CK levels in both groups were decreased when compared with those before treatment,while levels of IgA and IgG were evidently increased(P<0.05).CK levels in the treatment group were lower than those in the control group,while levels of IgA,IgG were higher than those in the control group,differences being significant(P < 0.05).Comparisons of levels of ALT and SCr between the two groups before and after treatment showed no significance in differences(P>0.05).ConclusionThe therapy of additional Xiyanping injection based on the conventional treatment can improve the curative effect for rotavirus enteritis,enhance the immune function and shorten the hospitalization time.During medication,the therapy did no adverse reaction has been found.

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欧阳学认,刘华,许华,陈思思,温惠红.喜炎平注射液治疗轮状病毒肠炎临床观察[J].新中医,2018,50(2):78-80

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  • 在线发布日期: 2018-02-08
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