Objective： To observe the clinical effect of modified Gegen tang combined with manipulative reduction for scapulohumeral periarthritiswith cold-dampnessimpeding syndrome.Methods：Divided 128 casesof patientswith scapulohumeral periarthritis of cold-dampness impeding syndrome into the control group and the observation group randomly，64 cases in each group.Based on manipulative reduction，the control group was additionally given the oral administration of Xiaohuoluo pills，while the observation group was additionally given the internal administration of modified Gegen tang.Evaluated the pain before and after treatment by simplified McGill pain questionnaire(SF-MPQ)and shoulder joint function by using rating scale of shoulder joint function as well as rating scale of American shoulder and elbow surgeons(ASES)，and observed the improvement of Chinese medicine symptoms of patients.ResultsAfter treatment，the total effective rate was 95.00%in the observation group，being higher than 83.05%in the control group.Pain rating index(PRI)，visual analogue scale(VAS)，present pain index(PPI)，and the total scores in both groups were all decreased when compared with those before treatment(P ＜ 0.01)；PRI，VAS，PPI，and the total scores in the observation group were all lower than those in the control group(P ＜ 0.01).After treatment，five scores of shoulder joint function and the total scores in both groups were all increased when compared with those before treatment(P ＜ 0.01)；five scores of shoulder joint function and the total score in the observation group were all higher than those in the control group(P ＜ 0.01).After treatment，Chinese Medicine syndrome scores in both groups were decreased when compared with those before treatment(P ＜ 0.01)，while ASES scores were both increased when compared with those before treatment(P ＜ 0.01)；Chinese Medicine syndrome scores in the observation group were lower than those in the control group(P ＜ 0.01)，while ASES scores in the observation group were higher than those in the control group(P＜0.01).Conclusion：The therapy of modified Gegen tang combined with manipulative reduction for scapulohumeral periarthritis with cold-dampness impeding syndrome can effectively improve shoulder joint function of patients，relieve pain，and has significant clinical effect.