Objective：To observe the effect of Chinese herbal compound based on triple-stage syndrome differentiation on biochemical indexes of patients with senile osteoporotic hip fracture.Methods：Divided 60 cases of patients with senile osteoporotic hip fracture randomly into Chinese herbal compound group with 30 cases and the control group with 30 cases.Both groups received minimally invasive fixation for fractures according to standard operation procedure.Chinese herbal compound group received the treatment of Chinese herbal medicine based on triple-stage syndrome differentiation：modified Zengye tang and Yigu tang according to the changes of syndromes during the first two weeks after surgery；modified Guipi tang and Yigu tang according to the changes of syndromes from the second week to the fourth week after surgery；modified Duhuo Jisheng tang and Yigu tang according to the changes of syndromes four weeks after surgery.The control group was forbidden from taking other relevant medicine affecting bone metabolism.Before surgery，in the 1stweek，2ndweek，1stmonth，and 3rdmonth after surgery，detected relevant biochemical indexes in blood of both groups respectively，including alkaline phosphatase(ALP)，calcium(Ca2+)，C-reactive protein(CRP)，plasma D-dimer and 25-hydroxyvitamin D[VD(25-OH)].Results：In the 1stweek，2ndweek，1st month and 3rd month after surgery，the levels of serum ALP，Ca2+and VD(25-OH)in Chinese herbal compound group were all significantly higher than those in the control group.Compared serum ALP levels between the two groups in 1 month and 3 months after surgery，differences being significant(P ＜ 0.05，P ＜ 0.01)；compared the serum Ca2+levels between the two groups in the 1stweek，and 2ndweek after surgery，differences being significant(P ＜0.05，P ＜ 0.01)；compared serum VD levels(25-OH)between the two groups in the 2ndweek，1stmonth and 3rdmonth after surgery，differences being significant(P＜0.05，P＜0.01).The levels of CRP，plasma D-dimer and VD(25-OH)in Chinese herbal compound group were all evidently lower than those in the control group in the 1st week，2ndweek，1stmonth and 3rdmonth after surgery.Compared CRP levels between the two groups in the 1stweek and 2ndweek after surgery，differences being significant(P＜0.05).Compared the two groups in 1 month and 3 months after surgery，differences being insignificant(P ＜ 0.05).Compared levels of plasma D-dimer between the two groups in the 2ndweek，1stmonth，and 3rdmonth after surgery，differences being significant(P＜ 0.05，P＜ 0.01).Conclusion：Reinforcing kidney and activating blood in the early stage with Chinese herbal compound based on triple-stage syndrome differentiation has a significant effect on biochemical indexes of patients with senile osteoporotic hip fracture.It can effectively improve body inflammation and hemagglutination in the early stage，improve the constitutional status of patients and promote bone formation，which can powerfully ensure quick recovery.