加味消渴健脾汤联合西药治疗脾虚湿盛型2型糖尿病临床观察
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R587.1

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Clinical Observation of Modified Xiaoke Jianpi Tang Combined with Western Medicine for Type 2 Diabetes Mellitus of Spleen Deficiency with Excessive Dampness Type
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    摘要:

    目的:观察加味消渴健脾汤联合西药治疗脾虚湿盛型2型糖尿病(T2DM)患者的临床疗效。方法:选取72例脾虚湿盛型T2DM患者,依照随机数字表法分为2组各36例。对照组仅予以西药治疗(盐酸罗格列酮片、盐酸二甲双胍片),观察组在对照组基础上加用加味消渴健脾汤治疗,2组均持续治疗4周。对比2组治疗前、治疗4周后的血糖指标[空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(P2hBG)]及血清脂联素、内脂素水平,并比较2组的治疗效果及不良反应发生率。结果:治疗4周,观察组总有效率(91.67%)高于对照组(69.44%),差异有统计学意义(P<0.05)。2组FBG、HbA1c、P2hBG水平均较治疗前降低(P<0.05),观察组上述指标水平均低于对照组(P<0.05)。2组血清脂联素水平均较治疗前提高(P<0.05),血清内脂素水平均较治疗前降低(P<0.05);观察组血清脂联素水平高于对照组(P<0.05),血清内脂素水平低于对照组(P<0.05)。治疗期间,2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:以加味消渴健脾汤联合西药治疗脾虚湿盛型T2DM患者效果显著,可明显改善血糖与脂联素、内脂素水平,减轻胰岛素抵抗,且安全性高。

    Abstract:

    Objective:To observe the clinical effect of modified Xiaoke Jianpi tang combined with western medicine for patients with type 2 diabetes mellitus(T2DM)of spleen deficiency with excessive dampness type.Methods:Selected 72 cases of patients with T2DM of spleen deficiency with excessive dampness type and divided them into two groups according to random number table method,36 cases in each group.The control group only received western medicine for treatment which included rosiglitazone hydrochloride tabletsand metformin hydrochloride tablets,while the observation group additionally received modified Xiaoke Jianpi tang based on the treatment of the control group.Both groups continuously received treatment for 4 weeks.Compared blood glucose indexes which included fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c)and postprandial 2 h blood glucose(P2hBG)as well as levels of serum adiponcetin and visfatin in both groups before treatment and after four weeks of treatment.Compared the curative effect and incidence of adverse reaction in both groups.Results:After treatment of four weeks,the total effective rate was 91.67%in the observation group,higher than that in the control group,which was 69.44%,the difference being significant(P<0.05).Levels of FBG,HbA1c and p2hBG in both groups were decreased when compared with those before treatment(P<0.05).Levels of the above indexes in the observation were lower than those in the control group(P<0.05).Levels of serum adiponcetin in both groups were increased when compared with those before treatment(P < 0.05),while levels of serum visfatin were decreased when compared with those before treatment(P<0.05).Levels of serum adiponcetin in the observation group were higher than those in the control group(P<0.05),while levels of serum visfatin were lower than those in the control group(P< 0.05).No significant difference was found in the comparison of incidence of adverse reaction between the two groups during treatment(P>0.05).Conclusion:The therapy of modified Xiaoke Jianpi tang combined with western medicine has a significant effect in treating patients with T2DM of spleen deficiency with excessive dampness type,which can obviously improve levels of blood glucose,adiponcetin and visfatin as well as relieve insulin resistance with high safety.

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程媛.加味消渴健脾汤联合西药治疗脾虚湿盛型2型糖尿病临床观察[J].新中医,2018,50(4):89-92

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  • 在线发布日期: 2018-04-10
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