Objective： To observe the clinical effect of Yanghe Jianpi tang for arteriosclerosis obliterans of lower extremities(ASO).Methods：Divided 66 cases of patients with ASO into two groups randomly，33 cases in each group.The control group received basic treatment of alprostadil，while the observation group additionally received Yanghe Jianpi tang based on the treatment of the control group.Results：The total effective rate was 72.7%in the control group and was 97.0%in the observation group，the difference being significant(P ＜ 0.05).After treatment，compared changes of scores of pain，sense of coldness and ABI，as well as skin temperature before and after treatment between the two groups，differences being significant(P＜0.05).The respective comparisons of above indexes between the two groups showed significance in differences(P ＜ 0.05).After treatment，no significant difference was found in the comparisons of indexes of triglyceride and high density lipoprotein cholesterol between the two groups(P＞0.05).The comparisons of total cholesterol and low density lipoprotein cholesterol between the two groups showed significance in differences(P＜0.05).Conclusion：Yanghe Jianpi tang can effectively improve symptoms of patients，reduce blood viscosity and significantly improve acral microcirculation，sense of coldness and pain，which is worthy of clinical application.