Objective: To observe the effect of Qianggu Huoxue tang combined with salmon calcitonin on serum osteocalcin,insulin-like growth factor and bone mineral density of patients with senile osteoporotic femoral neck fracture.M e th o d s:Divided 172 cases of patients with senile osteoporotic femoral neck fracture admitted in our hospital into two groups according to random number table method,86 cases in each group.The control group received salmon calcitonin for treatment,while the observation group additionally received Qianggu Huoxue tang based on the treatment of the control group.Compared the improvement of the clinical symptoms, the clinical effect, recent rehabilitation condition, serum osteocalcin,insulin-like growth factor,bone mineral density and safety in the two groups.Results:The total effective rate was 98.84%in the observation group,higher than that of 89.53%in the control group,the difference being significant(P <0.05).Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the scores in the observation group were lower than those in the control group;levels of serum osteocalcin,insulin-like growth factor and bone mineral density in the two groups were increased when compared with those before treatment,and the above three levels in the observation group were higher than those in the control group,differences being significant(P<0.05).The detumenscence time,healing time and ambulation time in the observation group were obviously shorter than those in the control group,differences being significant(P<0.05).No obvious adverse reaction was found in the two groups.C o n c lu s io n:The therapy of Qianggu Huoxue tang combined with salmon calcitonin has significant effect in treating patients with senile osteoporotic femoral neck fracture, which can effectively shorten the rehabilitation time, improve levels of osteocalcin and insulin-like growth factor and increase bone mineral density with high safety.