体外高频热疗联合健脾理气抑瘤方治疗晚期肝细胞癌临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R735.7

基金项目:

广东省科技发展专项资金项目(公益研究与能力建设方向) (2016A020226009)


Clinical Study of External High Frequency Thermo therapy Combined with Jianpi Liqi Yiliu Prescription for Advanced Hepatocellular Carcinoma
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察体外高频热疗联合健脾理气抑瘤方治疗晚期肝细胞癌(H C C)患者的临床疗效。方法:将4 1例晚期H C C患者根据是否愿意接受体外高频热疗分为联合治疗组及中药组。联合治疗组采用体外高频热疗联合健脾理气抑瘤方口服治疗;中药组单纯采用健脾理气抑瘤方治疗。均接受3周期以上的治疗。观察2组患者的疾病控制率(D C R)、疾病进展时间(T T P)、总体生存期(O S)、美国东部协作组(E C O G)体力状况评分(P S)及不良反应。截至2014年3月3 1日,脱落1例,纳入统计4 0例,2组均20例。结果:2组近期临床疗效联合治疗组D C R为25.0%,中药组D C R为15.0%。联合治疗组略高于中药组,但差异无统计学意义(P>0.05)。联合治疗组T T P为4.5月,中药组为3.1月,2组比较,差异有统计学意义(P<0.01)。联合治疗组O S为6.6月,中药组为5.5月,2组比较差异有统计学意义(P<0.01)。治疗后,与本组治疗前比较,2组P S评分均降低,差异均有统计学意义(P<0.05)。且联合治疗组P S评分降低更明显,2组间比较,差异有有统计学意义(P<0.05)。观察过程中,2组患者均未见因不良反应而终止治疗,未出现明显的血液学、胃肠道及肝肾毒性反应,未出现治疗相关的死亡。结论:体外高频热疗联合健脾理气抑瘤方能够延长晚期H C C患者的疾病进展时间和总体生存期,同时改善患者的体力状况,疗效均优于单纯中药健脾理气抑瘤方,二者联合治疗具有协同作用,且不良反应小。

    Abstract:

    Objective:To observe the clinical effect of external high frequency thermo therapy combined with Jianpi Liqi Yiliu prescription for advanced hepatocellular carcinoma.M e th o d s:Divided 41 cases of patients with advanced HCC into the combination treatment group and the Chinese medicine group according to whether they were willing to receive external high frequency thermo therapy.The combination treatment group adopted external high frequency thermo therapy combined with oral Jianpi Liqi Yiliu prescription,while the Chinese medicine group was given simple Jianpi Liqi Yiliu prescription.Both groups received more than 3 cycles of treatment.Observed the disease control rates(DCR),time to progression(TTP),overall survival(OS),physical condition score(PS)of Eastern Collaborative Oncology Group(ECOG)and adverse reactions in the two groups.As of March 31,2014,1 case had fallen off and 40 cases had been included in the statistics with 20 cases in each group.Results:The DCR of the recent clinical effect was 25.0%in the combination treatment group and was 15.0%in the Chinese medicine group.The combination treatment group was slightly higher than the Chinese medicine group,but the difference was insignificant(P>0.05).The TTP was 4.5 months in the combination treatment group and was 3.1 months in the Chinese medicine group,difference being significant(P<0.01).The OS was 6.6 months in the combination treatment group and was 5.5 months in the Chinese medicine group,difference being significant(P < 0.01).After treatment,the scores of PS in both groups were both decreased when compared with those before treatment,differences being significant(P < 0.05).The score of PS in the combination treatment group was decreased more obviously,difference being significant(P<0.05).During the observation, there was no treatment stopped due to adverse reactions in the two groups, and there were no obvious hematological,gastrointestinal,and hepatic and renal toxicity reactions,and no treatment-related deaths.Conclusion:The therapy of external high frequency thermo therapy combined with Jianpi Liqi Yiliu prescription can prolong the disease progression time and overall survival of patients with advanced HCC and improve the physical condition of patients.Its curative effect is better than that of the simple Jianpi Liqi Yiliu prescription in Chinese medicine.The combined treatment of the two has a synergistic effect and a small adverse reaction.

    参考文献
    相似文献
    引证文献
引用本文

周宇姝,招柏明,张晓轩,龙顺钦,杨小兵,吴万垠.体外高频热疗联合健脾理气抑瘤方治疗晚期肝细胞癌临床研究[J].新中医,2018,50(6):184-188

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2018-06-05
  • 出版日期: