Objective：To observe the improvement of acupoint tuina combined with lumbar three needles for pain and dysfunction of lumbar disc herniation，and observe the effect of the therapy on the levels of superoxide dismutase(SOD)and α 1-acid glycoprotein(α 1-AGP)in serum.M e th o d s：Divided 76 cases of patients with lumbar disc herniation into two groups according to the random number table method，38 cases in each group.The control group was treated with computer medium frequency therapy combined with acupoint tuina，while the observation group received acupoint tuina combined with lumbar three needles for treatment.The two groups received treatment for three courses，one month being one course.After treatment， observed the clinical effect of patients， measured levels of SOD and α 1-AGP， and scored the pain and dysfunction of patients through the method of visual analogue score(VAS)and the questionnaire of Oswestry disability index(ODI).Results：The total effective rate was 73.7% in the control group and was 97.4% in the observation group，the difference being significant(P ＜ 0.05).After treatment，levels of SOD and α 1-AGP were improved when compared with those before treatment，differences being significant(P ＜ 0.05).The SOD level in the observation group was higher than that in the control group，and the level of α 1-AGP was lower than that in the control group，differences being significant(P ＜ 0.01).After treatment，the comparison of pain degree between the two groups showed significance in the difference(P ＜ 0.05)，and the pain degree in the observation group was better than that in the control group.The VAS score and total scores of ODI in the two groups were decreased when compared with those before treatment，differences being significant(P ＜ 0.05).After treatment， the VAS score and total scores of ODI in the observation group were lower than those in the control group，differences being significant(P ＜ 0.05).Scores of activity，sleep，travel and life in the observation group were lower than those in the control group，differences being significant(P＜0.05).No obvious adverse reactions occurred during the treatment in patients of the two groups.Conclusion：The therapy of acupoint tuina combined with lumbar three needles for lumbar disc herniation can significantly relieve the pain of patients，improve functional disorder，regulate levels of SOD and α 1-AGP in serum，and improve oxidative stress reactions and inflammatory responses in the body.