Objective：To observe the clinicaleffect of the therapy of counteracting toxin with toxin for rheumatoid arthritis.Methods：Divided 480 cases of patients with rheumatoid arthritis into 7 types including the wind-toxin arthralgia syndrome，the cold-toxin arthralgia syndrome，the humiditytoxin syndrome the heat-toxin arthralgia syndrome，the phlegm-toxin arthralgia syndrome，the stasis-toxin arthralgia syndrome and the deficiency-toxin arthralgia syndrome.During syndrome differentiation and typing，mainly selected the wind-dampness dispelling Chinese herbal medicine with certain toxicity and assisted in other treatments.Results：Clinical remission in 216 cases，improvement in 242 cases，ineffectiveness in 22 cases，the effective rate was 95.2% ；in terms of Chinese medicine syndrome，clinical remission in 230 cases，remarkable effectiveness in 144 cases，effectiveness in 87 cases，ineffectiveness in 19 cases，the total effective rate was 96.0%.Conducted follow-ups of 216 cases with clinical remission，130 cases had no recurrence.After treatment，comparing with those before treatment，the time of morning stiffness，index of joint pain，index of joint swelling，handgrip strength and dysfunction of joint were all improved，and the levels of erythrocyte sedimentation rate(ESR)，C-reactive protein(CRP)and rheumatoid factor(RF)were decreased respectively，differences being significant(P ＜ 0.01).Conclusion：The therapy of counteracting toxin with toxin has both good long-termand short-termclinicaleffect in treating rheumatoid arthritis.