补阳还五汤治疗女性精神分裂症焦虑症状临床观察
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R749.3

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福州市科技计划项目(2016-S-126-1)


Clinical Observation of Buyang Huanwu Tang for Anxiety Symptoms of Female Schizophrenia
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    摘要:

    目的:观察补阳还五汤治疗女性精神分裂症焦虑症状的临床疗效。方法:将精神分裂症女性患者70例随机分为对照组和观察组各35例。对照组予常规抗精神病药物治疗,观察组在对照组基础上服用补阳还五汤,2组均治疗6周。比较2组临床疗效,治疗前、治疗后2周、4周、6周汉密顿焦虑量表(HAMA)评分和焦虑因子分(包括躯体性焦虑和精神性焦虑),评估2组不良反应发生情况。结果:治疗6周后,愈显率观察组为77.1%,对照组为31.4%,2组比较,差异有统计学意义( P <0.05)。治疗2周、4周、6周后,2组HAMA评分与前一时间点比较均下降( P <0.05);治疗2周后,2组HAMA评分比较,差异无统计学意义( P >0.05),治疗4周、6周后,观察组HAMA评分均较对照组下降更明显( P <0.05)。治疗2周、4周、6周后,对照组精神性焦虑评分、观察组躯体性焦虑评分、精神性焦虑评分均较治疗前下降( P <0.05),对照组躯体性焦虑评分与治疗前比较,差异无统计学意义( P >0.05)。治疗2周、4周、6周后,2组精神性焦虑评分均较同组前一时间点降低( P <0.05),同一时间点观察组精神性焦虑评分和对照组比较,差异均无统计学意义( P >0.05);治疗4周、6周后,观察组躯体性焦虑评分与对照组比较均降低( P <0.05)。2组不良反应发生情况比较,差异无统计学意义( P >0.05)。结论:补阳还五汤能改善精神分裂症患者的焦虑症状,对躯体性焦虑的改善更明显,可用于精神分裂症的辅助治疗。

    Abstract:

    Objective:To observe the clinicaleffect of BuyangHuanw u tang for anxiety symptoms of fem ale schizophrenia.Methods:Divided 70 cases of fem ale patients with schizophrenia into the controlgroup and the observation group randomly,35 cases in each group.The control group was given the routine antipsychotic drugs,while the observation group additionally received the oral administration of BuyangHuanw u tang.The treatment for both groups lasted for 6 weeks.Compared the clinical effect,scores of Hamilton anxiety scale(HAMA)and anxiety scores(including som atic anxiety and psychic anxiety)in both groups before treatment and after treatment for 2 weeks,4 weeks and 6 weeks,and evaluated the occurrence of adverse reactions in both groups.Results:After 6 weeks of treatment,the total obvious effective rate was 77.1%in the treatment group and 31.4%in the controlgroup,difference being significant( P <0.05).After 2,4 and 6 weeks of treatment,the scores of HAMA in both groups were all lower than those in the previous time points( P <0.05);after 2 weeks of treatment,comparing the scores of HAMA in the two groups,there was no significant difference being found( P > 0.05),and after 4 and 6 weeks of treatment,the scores of HAMA in the observation group were decreased more significantly than those in the control group( P <0.05).After 2,4 and 6 weeks of treatment,the psychic anxiety score in the control group,and som atic anxiety score and psychic anxiety score in the observation group were lower than those before treatment( P <0.05);comparing the som atic anxiety score in the controlgroup with that before treatment,there was no significant difference being found( P > 0.05).After 2,4 and 6 weeks of treatment,the psychic anxiety scores of both groups were all lower than those of the same group in the previous time points( P <0.05);comparing the psychic anxiety scores of the observation group in the same time point with that in the control group,there were no significant differences being found( P > 0.05);after 4 and 6weeks of treatment,the som atic anxiety scores in the observation group were lower than those in the control group( P <0.05).Comparing the occurrence of adverse reactions in the two groups,there was no significant difference being found( P >0.05).Conclusion:BuyangHuanw u tang can improve the anxiety symptoms of patients with fem ale schizophrenia while som atic anxiety can be improved more significantly,which can be applied in the adjuvant treatment for schizophrenia.

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林巧,纪家武,官芳萍,罗兰珠,胡耀华,丘骏,陈文辉.补阳还五汤治疗女性精神分裂症焦虑症状临床观察[J].新中医,2018,50(9):58-61

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  • 在线发布日期: 2018-09-04
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