黄葶散外敷配合抗结核药物治疗结核性渗出性胸膜炎临床观察
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R521.7

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青岛市家庭中医药适宜技术的筛选及软件服务包开发项目(2014-zyz002)


Clinical Observation of the External Application of Huang ting Powder Combined with An ti-tubercu losis Medicine for Tuberculous Exudative Pleurisy
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    摘要:

    目的:观察黄葶散外敷配合抗结核药物治疗结核性渗出性胸膜炎的临床疗效。方法:将192例结核性渗出性胸膜炎患者随机分为观察组和对照组各96例。观察组给予黄葶散外敷、标准化抗结核、胸腔穿刺抽液等治疗,对照组给予标准化抗结核、胸腔穿刺抽液等治疗;2组均以1月为1疗程,共治2疗程;期间观察2组临床疗效、胸腔积液完全吸收率、胸腔积液肿瘤坏死因子α(TNF-α)、转化生长因子β1(TGF-β1)浓度及并发症情况。结果:治疗1疗程,总有效率观察组为93.6%,对照组为83.3%,2组比较,差异有统计学意义( P <0.05)。治疗2疗程,总有效率观察组为96.8%,对照组为91.7%,2组比较,差异无统计学意义( P >0.05)。治疗后,观察组胸腔积液TNF-α、TGF-β1浓度均较对照组明显下降,2组比较,差异均有统计学意义( P <0.05)。积液完全吸收率观察组为76.6%,对照组为62.5%,2组比较,差异有统计学意义( P <0.05)。胸腔积液包裹、黏连发生率观察组为6.4%,对照组为15.6%,2组比较,差异有统计学意义( P <0.05)。结论:黄葶散外敷配合抗结核药物较单纯抗结核药物治疗结核性渗出性胸膜炎可提高临床疗效,改善积液中炎症因子水平。

    Abstract:

    Objective: To observe the clinical effect of the external application of Huangting powder com bined with anti-tuberculosis medicine for tuberculous exudative pleurisy.Methods:Divided 192 cases of patients with tuberculous exudative pleurisy admitted in our hospital into the observation group and the controlgroup randomly,96 cases in each group.The observation group received such treatments as external application of Huangting powder ,standardized anti-tuberculosis and thoracentesis aspiration,while the control group was given treatments including standardized anti-tuberculosis and thoracentesis aspiration.The two groups received treatment for two courses,one months being a course.During treatment,observed the clinical effect,the total absorption rate of pleural effusion,the concentration of tumor necrosis factor α(TNF-α )and transforming grow th factorβ 1(TGF-β 1)in pleuraleffusion,and the incidence of complications in both groups.Results:After one course of treatment,the totaleffective rate was 93.6%in the observation group and 83.3%in the control group,difference being significant( P <0.05).After two courses of treatment,the total effective rate was 96.8%in the observation group and 91.7%in the controlgroup,difference being insignificant( P > 0.05).After treatment,the concentration of TNF-α and TGF-β 1 in the observation group was significantly lower than that in the control group,differences being significant( P <0.05).The total absorption rate of effusion was 76.6%in the observation group and 62.5%in the control group,difference being significant( P <0.05).The incidence of encapsulation and adhesion of pleuraleffusion was 6.4%in the observation group and 15.6%in the control group,difference being significant( P <0.05).Conclusion:Compared with the simple application of anti-tuberculosis medicine,the external application of Huangting powder com bined with anti-tuberculosis medicine for tuberculous exudative pleurisy can enhance the clinical effect,and improve the level of inflamm atory factors in effusion.

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苏海涛,李同霞,戚艳,吕洪清.黄葶散外敷配合抗结核药物治疗结核性渗出性胸膜炎临床观察[J].新中医,2018,50(9):61-64

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  • 在线发布日期: 2018-09-04
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