五行音乐联合一贯煎加减治疗轻中度围绝经期焦虑症临床观察
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R271.11+6

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浙江省中医药科技计划项目(2016ZA222)


Clinical Observation on Five-element Music Com bined with Mod ified Yiguan jian for Mild-to-moderate Anxiety Du ring Perimenopause
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    摘要:

    目的:观察五行音乐联合一贯煎加减治疗围绝经期焦虑症患者的临床疗效。方法:将最终完成研究的轻中度围绝经期焦虑症患者75例,分为对照1组25例、对照2组20例和治疗组30例。对照1组予一贯煎治疗,对照2组予五行音乐治疗,治疗组予五行音乐联合一贯煎治疗。每天1次,1月为1疗程,3组均治疗2疗程。比较治疗前后汉密尔顿焦虑量表(HAMD)评分和Kupperman评分,检测3组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH) 及抗苗勒氏管激素(AMH) 水平。结果:治疗后,对照1组、治疗组HAMD和Kupperman评分均较治疗前降低( P <0.05),对照2组HAMD和Kupperman评分与治疗前比较无差异( P >0.05);治疗组HAMD和Kupperman评分较对照1组、对照2组降低更明显( P <0.05),对照1组HAMD和Kupperman评分较对照2组降低更明显( P <0.05)。治疗后,对照1组血清FSH水平较治疗前降低( P <0.05),较对照2组亦降低( P <0.05);对照1组血清LH、AMH水平与治疗前比较,差异无统计学意义( P >0.05),与对照2组比较,差异无统计学意义( P >0.05)。治疗后,对照2组血清FSH、LH、AMH水平与治疗前比较,差异无统计学意义( P >0.05)。治疗后,治疗组血清FSH、LH水平均较治疗前降低( P <0.05),较对照1组、对照2组血清FSH、LH水平亦降低( P <0.05);治疗组AMH水平与治疗前比较,差异无统计学意义( P >0.05),与对照1组、对照2组比较,差异无统计学意义( P >0.05)。治疗后,总有效率对照1组为64.0%,对照2组为20.0%,治疗组为86.6%,3组分别比较,差异均有统计学意义( P <0.05)。结论:中药一贯煎在治疗围绝经期焦虑症方面疗效明确,若联合五行音乐疗法,能更好的改善焦虑症状及其他躯体不适。

    Abstract:

    Objective:To observe theclinical effect of five-elementmusic com bined with modified Yiguanjian for patients with anxiety during perimenopause.Methods:Divided 75 cases of patients completed in the final study with mild-to-moderate anxiety during perimenopause into the control group 1,the control group 2 and the treatment group,25,20 and 30 cases in each group respectively.The control group 1 was treated with Yiguanjian;the control group 2 received five-element music for treatment;the treatment group was given five-element music com bined with Yiguanjian for treatment.The three groups were treated once a day,and the treatment lasted for two courses,one month being one course.Compared scores of Hamilton depression scale(HAMD)and Kupperm an scores before and after treatment.Detected levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH)and anti-mullerian hormone(AMH)in serum before and after treatment.Results:After treatment,scores of HAMD and Kupperm an in the control group 1 and the treatment group were decreased when compared with those before treatment( P <0.05).Compared scores of HAMD and Kupperm an in the control group 2 before and after treatment,there were no significance in the differences( P > 0.05).Scores of HAMD and Kupperm anin the treatment group were decreased more obviously than those in the control group 1 and group 2( P <0.05).Scores of HAMD and Kupperm an in the controlgroup 1 were decreased more obviously than those in the controlgroup 2( P <0.05).After treatment,the FSH level in serumin the control group 1 was decreased when compared with that before treatment( P <0.05),and was decreased when compared with that in the controlgroup 2( P <0.05).Compared levels of LHand AMH in the control group 1 before and after treatment,there were no significance in the differences( P > 0.05).Compared levels of LH and AMH in the control group 1 with those in the control group 2,there were no significance in the differences(P> 0.05).After treatment,compared levels of FSH,LH and AMH in serumin the control group 2 before and after treatment,there were no significance in the differences( P > 0.05).Levels of FSH and LH in serumin the treatment group were decreased when compared with those before treatment( P <0.05),and were decreased when compared with those in the control group 1 and the control group 2( P <0.05).Compared the AMH level in the treatment group before and after treatment,there was no significance in the difference( P > 0.05).Compared the AMH level in the treatment group with that in the controlgroup 1 and the controlgroup 2,there was no significance in the difference( P > 0.05).After treatment,the total effective rate was 64.0%in the control group 1,20.0%in the control group 2 and 86.6%in the treatment group,differences being significant( P <0.05).Conclusion:Yiguanjian has a definite effecton the treatmentof anxiety in perimenopause.If com bined with five-elementmusic therapy,it can better improve anxiety symptoms and other physicaldiscom fort.

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姜云,王红卫,王芸,徐金贵.五行音乐联合一贯煎加减治疗轻中度围绝经期焦虑症临床观察[J].新中医,2018,50(9):123-126

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  • 在线发布日期: 2018-09-04
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