针刺预处理治疗前列腺增生TURP术后早期认知功能障碍临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R697+.3

基金项目:

国家自然科学基金项目 (U1304809)


Clinical Study of Acupuncture Precond itioning for Prostatic Hypertrophy with Postoperative Congnitive Dysfunction in Early Stage
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨针刺预处理治疗前列腺增生经尿道前列腺气化电切手术(TURP)术后早期认知功能障碍(POCD)的临床疗效。方法:选取前列腺增生拟行TURP手术治疗的男性患者90例,随机分为对照组和观察组各45例。对照组予术前常规处理,观察组在对照组基础上予针刺预处理百会穴,双侧内关和足三里穴。2组均在术前连续治疗3天。比较2组术后第1天、第3天POCD发病率和术前、术后第1天、第3天血清神经元特异性烯醇化酶(NSE)和S-100β蛋白含量。结果:术后第1天POCD发病率对照组为24.44%,观察组为13.33%,2组比较,差异有统计学意义( P <0.05);术后第3天POCD发病率对照组为11.11%,观察组为2.22%,2组比较,差异有统计学意义( P <0.05)。术后第1天,2组血清NSE和S-100β蛋白含量均较术前升高( P <0.05),对照组血清NSE和S-100β蛋白含量较观察组升高更明显( P <0.05)。术后第3天,对照组血清NSE和S-100β蛋白含量较术前升高( P <0.05),但较术后第1天降低( P <0.05);观察组血清NSE和S-100β蛋白含量与术前比较,差异无统计学意义( P >0.05),与对照组血清NSE和S-100β蛋白含量比较仍降低( P <0.05)。结论:针刺预处理治疗前列腺增生TURP术后认知障碍,可有效降低患者术后认知障碍的发病率,降低术后血清NSE、S-100β蛋白水平,其机制可能与针刺预处理降低了围手术期麻醉手术等因素对脑组织的损害有关。

    Abstract:

    Objective: To discuss the clinical effect of acupuncture preconditioning for prostatic hypertrophy with postoperative congnitive dysfunction(POCD)in early stage after an operation of transurethral resection of the prostate(TURP).Methods:Selected 90 cases of male patients with prostatic hypertrophy who were planned to receive TURP operation randomly,and divided theminto the controlgroup and the observation group,45 cases in each group.The controlgroup was given preoperative routine treatment,while the observation group was given acupuncture preconditioning at acupoints of Baihui,Neiguan and Zusanliof both sides.Both groups were treated consecutively for 3 days beforeoperation.Compared the incidence of POCD on the 1st and 3rd day after operation with the content of neuron-specific enolase(NSE)and S-100β protein in serum before operation and on the 1st and 3rd day after operation in the two groups.Results:One day after operation,the incidence of POCD was 24.44%in the control group and 13.33%in the observation group,difference being significant( P <0.05).Three days after operation,the incidence of POCD was 11.11%in the control group and 2.22%in the observation group,difference being significant( P <0.05).One day after operation,the content of NSE and S-100β protein in serumin the two groups were increased when compared with that before operation( P <0.05).The contents of NSE and S-100β protein in serumin the control group were increased more obviously when compared with that in the observation group( P <0.05).Three days after operation,the contents of NSE and S-100β protein in serumin the control group were higher than those before operation( P <0.05),but lower than those on the 1st day after operation( P <0.05).There were no significant differences being found in the comparison of the contents of NSE and S-100β protein in serumin the observationgroup with those before operation( P >0.05).But the contents of NSE and S-100β protein in serumin the observation group were lower when compared with those in the control group( P <0.05).Conclusion:The application of acupuncture preconditioning for prostatic hypertrophy with POCD after TURP can effectively reduce the incidence of POCD and lower the levels of NSE and S-100β protein in serum after operation.Its mechanism m ay be relevant to the effect of acupuncture preconditioning in reducing the dam age to brain tissues caused by perioperative anesthesia and other factors.

    参考文献
    相似文献
    引证文献
引用本文

杨木强,闫俊强,张沛,张红军,郭丹.针刺预处理治疗前列腺增生TURP术后早期认知功能障碍临床研究[J].新中医,2018,50(9):192-195

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2018-09-04
  • 出版日期: