Objective：To observe the clinical effect of Qingli Huayu tang for chronic nephritic proteinuria.Methods：Divided 62 cases of patients with chronic nephritic proteinuria into two groups randomly，31 cases in each group.The control group was given losartan potassium tablets，while the observation group was additionally given Qingli Huayu tang.The course of treatment lasted for 3 months.Observed Chinese medicine symptom scores and such indexes as urinary albumin，urinary microalbumin，24-hour urine protein quantitation，renal function and cystatin C in both groups before and after treatment，and evaluated the clinical effect.Results：The total effective rate of proteinuria was 93.54%in the observation group and 70.96%in the control group，difference being significant(P＜0.05).After treatment，symptom scores in the observation group were significantly decreased，and there were significant differences being found when comparing with those before treatment and those in the control group after treatment(P＜0.05).The symptom scores in the control group were not significantly improved(P＞0.05).After treatment，the levels of urinary microalbumin and 24-hour urine protein quantitation in both groups were lower than those before treatment(P＜0.05)； the indexes above in the observation group were improved more significantly than those in the control group(P＜0.05).After treatment，there was little change of serum creatinine and urea nitrogen in both groups，and there were no significant differences being found when comparing with those before treatment(P＞0.05).There was little change of cystatin C in the control group before and after treatment(P＞0.05)；the level of cystatin C in the observation group was decreased significantly after treatment，and there was significant difference being found when comparing with that before treatment(P＜0.05).Conclusion：Qingli Huayu tang can reduce nephritic proteinuria，ameliorate the clinical symptoms of patients and improve early renal function impairment，thus to delay the progression of kidney disease.