丹红注射液治疗椎-基底动脉供血不足性眩晕临床疗效系统评价
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A SystematicEvaluation ofClinicalEffectofDanhong Injection onVertigo of Vertebrobasilar Artery Insufficiency
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    摘要:

    目的:系统评价丹红注射液对椎-基底动脉供血不足性眩晕的治疗效果及安全性。方法:计算机检索CNKI、PubMed、EMbase、CBM和万方等数据库,查找丹红注射液治疗椎-基底动脉供血不足性眩晕的随机对照试验。按纳入和排除标准由两名评价者独立选择试验、提取资料,交叉核对并进行方法学质量评估,对同质研究采用RevMan 5.3软件进行Meta分析。结果:Meta分析结果显示:与西药组比较,丹红注射液治疗椎-基底动脉供血不足性眩晕的临床总有效率提高(OR=4.65,95%CI=3.12~6.93),椎基底动脉血流速度(WMD=2.51,95%CI=2.31~2.71)、高切比黏度(WMD=-0.17,95%CI=0.29~-0.05)、低切比黏度(WMD=-0.42,95%CI=-0.78~-0.06)、血浆比黏度 (OR=-0.08,95%CI=-0.15~-0.01)、纤维蛋白原水平 (OR=-0.39,95%CI=-0.61~ -0.18)、血细胞比容 (OR=-1.73,95%CI=-3.00~-0.47)、总胆固醇水平 (WMD=-0.69,95%CI=-0.82~-0.56)、三酰甘油水平(WMD=-0.41,95%CI=-0.49~-0.33)、低密度脂蛋白胆固醇水平(OR=-0.29,95%CI=-0.48~-0.10) 均改善。结论:丹红注射液能有效改善椎-基底动脉供血不足,其效果优于单用西药治疗。

    Abstract:

    To systematically evaluate the therapeutic effect and safety of Danhong injection in treating vertigo of vertebrobasilar artery insufficiency.Methods:CNKI,PubMed,EMbase,CBM and Wanfang databases were searched through computer to find the randomized controlled trials of Danhong injection in the treatment of vertigo of vertebrobasilar artery insufficiency.According to the inclusion and exclusion criteria, two evaluators independently selected the trials,extracted the data,cross-checked and conducted methodological quality assessment.RevMan 5.3 software was used for Meta analysis of homogeneous studies.Results:The meta-analysis results showed that compared with the western medicine group,with the treatment of Danhong injection,the total clinical effect was improved(OR=4.65, 95%CI=3.12~6.93); the flow velocity of vertebrobasilar artery(WMD=2.51, 95%CI=2.31~2.71); the high-shear specific viscosity(WMD=-0.17,95%CI=0.29~-0.05),the low-shear specific viscosity(WMD=-0.42,95%CI=-0.78~-0.06),the specific viscosity of plasma(OR=-0.08, 95%CI=-0.15~-0.01), the fibrinogen level(OR=-0.39, 95%CI=-0.61~-0.18), the hematocrit(OR=-1.73,95%CI=-3.00~-0.47),the improvement of the levels of total cholesterol(WMD=-0.69,95%CI=-0.82~-0.56),triglyceride(WMD=-0.41,95%CI=-0.49~-0.33)and low density lipoprotein cholesterin(OR=-0.29,95%CI=-0.48~-0.10)were improved.Conclusion:Danhong injection can effectively improve the vertigo caused by vertebrobasilar artery insufficiency,and its effect is better than that of western medicine alone.

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王新琳,于强.丹红注射液治疗椎-基底动脉供血不足性眩晕临床疗效系统评价[J].新中医,2019,51(10):37-41

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  • 在线发布日期: 2019-10-11
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