怡神助眠汤联合西药唑吡坦治疗失眠症临床疗效及对脑内神经递质的影响
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R256.23

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浙江省医药卫生计划项目 (2015KYB366)


Clinical Effect of Yishen Zhumian Tang Combined with Zolpidem on Insomnia and Its Effect on Neurotransmitters in the Brain
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    摘要:

    目的:探讨怡神助眠汤联合西药唑吡坦治疗失眠症的疗效及对脑内神经递质的影响。方法:选取2017年7月—2018年7月温州市中医院收治的110例失眠症患者作为研究对象,采用系统回顾性分析法分析所有患者的临床资料,根据资料中不同的治疗方法将所有患者分为对照组和研究组,每组55例。对照组给予酒石酸唑吡坦治疗,研究组给予怡神助眠汤联合酒石酸唑吡坦治疗,2组均连续治疗4周。比较2组临床疗效、匹兹堡睡眠指数量表(Pittsburgh sleep quality index,PSQI)评分、脑内神经递质水平及不良反应发生率。结果:研究组临床治疗有效率为96.36%,明显高于对照组的76.36%(P<0.05);2组治疗后、治疗结束2个月后PSQI评分均明显低于治疗前(P<0.05);研究组治疗后和治疗结束2个月后PSQI评分均明显低于对照组(P<0.05);2组治疗后γ-氨基丁酸(γ-aminobutyric acid,GABA) 明显高于治疗前(P<0.05),且研究组治疗后GABA明显高于对照组(P<0.05);研究组治疗后5-羟色胺(5-hydroxytryptamine,5-HT) 明显高于治疗前和对照组(P<0.05);研究组不良反应发生率为3.64%,明显低于对照组的14.55%(P<0.05)。结论:中药怡神助眠汤联合西药唑吡坦治疗失眠症患者的临床疗效更为显著,且安全性高,其作用机制可能与升高脑内GABA、5-HT等神经递质水平有关。

    Abstract:

    To discuss the curative effect of Yishen Zhumian Tang combined with zolpidem on insomnia and its effect on neurotransmitters in the brain.Methods:A total of 110 patients with insomnia admitted to Wenzhou Hospital of Chinese Medicine from July 2017 to July 2018 were selected as research objects.The clinical data of all patients were analyzed by systematic retrospective analysis method.According to the different treatment methods in the data,all patients were divided into the control group and the study group,55 cases in each group.The control group was treated with zolpidem tartrate,and the study group was treated with Yishen Zhumian Tang combined with zolpidem tartrate.Both groups were treated for four weeks.Clinical effect,scores of Pittsburgh seep quality index(PSQI),levels of neurotransmitters in the brain and the incidence of adverse reactions were compared between the two groups.Results:The effective rate of clinical treatment in the study group was 96.36%,significantly higher than that of 76.36%in the control group(P<0.05).After treatment and two months after treatment,scores of PSQI in both groups were significantly decreased when compared with those before treatment(P < 0.05).After treatment and two months after treatment,the PSQI score in the study group was significantly lower than that in the control group(P < 0.05).After treatment,the levels of γ-aminobutyric acid(GABA)in the two groups were significantly higher than those before treatment(P < 0.05),and the GABA in the study group was significantly higher than that in the control group after treatment(P < 0.05).After treatment,the level of 5-hydroxytryptamine(5-HT)in the study group was significantly higher than that in the control group(P<0.05).The incidence of adverse reactions in the study group was 3.64%,significantly lower than that of 14.55%in the control group(P<0.05).Conclusion:The therapy of Yishen Zhumian Tang combined with zolpidem has significant therapeutic effect in treating patients with insomnia with high safety,whose mechanism may be related to increased levels of neurotransmitters such as GABA and 5-HT in the brain.

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朱政羽,赵娜,吴旭杰,胡万华.怡神助眠汤联合西药唑吡坦治疗失眠症临床疗效及对脑内神经递质的影响[J].新中医,2019,51(10):99-102

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  • 在线发布日期: 2019-10-11
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