云南白药胶囊联合质子泵抑制剂治疗消化性溃疡出血临床研究
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R573.1

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Clinical Study on Yunnan Baiyao Capsules Combined with Proton Pump Inhibitor for Bleeding Peptic Ulcer
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    摘要:

    目的:应用云南白药胶囊联合质子泵抑制剂治疗消化性溃疡出血,评估其临床疗效和安全性。方法:选取消化性溃疡出血患者100例,按随机数字表法分为对照组和研究组各50例。对照组常规治疗基础上应用质子泵抑制剂进行治疗,研究组在对照组基础上应用云南白药胶囊进行治疗。记录2组患者止血时间、输血量、胃肠道症状消失时间和住院时间;评估患者治疗前后胃肠道症状积分;检测2组患者治疗前后血红蛋白(Hb)水平。结果:研究组显效率为72.00%,高于对照组62.00%,差异有统计学意义(P<0.05)。研究组止血时间、输血量、胃肠道症状消失时间和住院时间均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组消化道症状积分和Hb水平比较,差异无统计学意义(P>0.05)。治疗后,2组消化道症状积分较治疗前降低,Hb水平较治疗前升高;且研究组消化道症状积分低于对照组,Hb水平高于对照组;差异均有统计学意义(P<0.05)。2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:云南白药胶囊联合质子泵抑制剂治疗消化性溃疡出血,临床疗效较好,能够显著缩短患者止血时间、胃肠道症状消失时间和住院时间,减少输血量。

    Abstract:

    To apply Yunnan Baiyao capsules combined with proton pump inhibitor for bleeding peptic ulcer,and to evaluate its clinical effect and safety.Methods:A total of 100 cases of patients with bleeding peptic ulcer were selected and divided into the control group and the study group according to the random number table method,50 cases in each group.The control group was treated with proton pump inhibitor based on routine treatment,and the study group was additionally treated with Yunnan Baiyao capsules based on the treatment of the control group.The hemostasis time,the blood transfusion volume,the disappearance time of gastrointestinal symptoms and the hospitalization time in the two groups were recorded;the scores of gastrointestinal symptoms before and after treatment were evaluated;the levels of hemoglobin(Hb)before and after treatment in the two groups were detected.Results:The significant effective rate was 72.00%in the study group,higher than that of 62.00%in the control group,the difference being significant(P < 0.05).The hemostasis time,the blood transfusion volume,the disappearance time of gastrointestinal symptoms and the hospitalization time in the study group were less than those in the control group,differences being significant(P < 0.05).Before treatment,there was no significant difference being found in the comparison of the scores of gastrointestinal symptoms and the levels of Hb in the two groups(P >0.05).After treatment,the scores of gastrointestinal symptoms in the two groups were decreased when compared with those before treatment,while the levels of Hb were increased;the score in the study group was lower than that in the control group,while the level of Hb was higher;differences being significant(P < 0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions in the two groups(P>0.05).Conclusion:The therapy of Yunnan Baiyao capsules combined with proton pump inhibitor in treating bleeding peptic ulcer has significant clinical effect,which can significantly shorten thehemostasistime,the disappearance timeof gastrointestinal symptomsand the hospitalization time and reduce the blood transfusion volume.

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章欣,陈华群,尤君芬.云南白药胶囊联合质子泵抑制剂治疗消化性溃疡出血临床研究[J].新中医,2019,51(10):119-121

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  • 在线发布日期: 2019-10-11
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