益气养阴方对妊娠期糖尿病患者脂肪因子及胰岛β细胞功能和妊娠结局的影响
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R714.256

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Effect of Qi-supplementing and Yin-nourishing Prescription on Adiponectin Factors,Islet β Cell Function and Pregnancy Outcomes in Patients with Diabetes during Pregnancy
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    摘要:

    目的:观察益气养阴方治疗妊娠期糖尿病(GDM)的临床疗效及对脂肪因子及胰岛β细胞功能和妊娠结局的影响。方法:将130例GDM随机分为2组各65例。对照组进行常规饮食控制,血糖如果控制无效则给予胰岛素进行治疗。观察组在对照组治疗基础上给予益气养阴方。对比2组治疗前后血清脂肪因子、胰岛β细胞功能改善情况和妊娠结局。结果:治疗后,2组空腹血糖(FBG)、餐后2 h血糖、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR) 较治疗前下降(P<0.05),观察组降低程度更为显著(P<0.05)。治疗后,2组脂联素(ADPN) 较治疗前升高(P<0.05),内脂素、抵抗素、瘦素(LP)、视黄醇结合蛋白-4(RBP-4)较治疗前降低(P<0.05)。观察组改善程度更为明显(P<0.05)。观察组治疗后各项不良妊娠结局发生率与对照组比较,差异有统计学意义(P<0.05)。结论:妊娠期糖尿病患者采用益气养阴方的治疗方法,可以明显改善血清脂肪因子、胰岛β细胞功能,降低不良妊娠结局发生率。

    Abstract:

    To observe the clinical effect of qi-supplementing and yin-nourishing prescription for diabetes mellitus(GDM)during pregnancy and its effects on adipokines factors, islet β-cell function and pregnancy outcomes.Methods:Divided 130 cases of GDM patients randomly into two groups with 65 cases in each group.The control group underwent routine diet control;if the blood glucose was not effective,insulin was administered.The observation group was additionally given qi-supplementing and yin-nourishing prescription on the basis of the treatment in the control group.Compared the improvement of serum adipokines factors and islet β-cell function and pregnancy outcomes in the two groups before and after treatment.Results: After treatment, the fasting blood glucose(FBG), postprandial 2 h blood glucose,glycosylated hemoglobin(HbA1c), fasting insulin(FINS), insulin resistance index(HOMA-IR)in the two groups were all decreased when compared with those before treatment(P < 0.05);the decrease in the observation group was more obvious(P < 0.05).After treatment,the adiponectin(ADPN)in the two groups were higher than those before treatment(P < 0.05);visfatin,resistin,leptin(LP)and retinol binding protein-4(RBP-4)were all decreased when compared with those before treatment(P<0.05).The improvement in the observation group was more obvious(P<0.05).There was significant deference being found in the comparison of the incidence of each adverse pregnancy outcome in the observation group after treatment with that in the control group(P<0.05).Conclusion:The application of qi-supplementing and yin-nourishing prescription for patients with diabetes during pregnancy can significantly improve serum adipokines factors and islet β cell function and reduce the incidence of adverse pregnancy outcomes.

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杨丽敏,张妙,沈雅玉,张丽.益气养阴方对妊娠期糖尿病患者脂肪因子及胰岛β细胞功能和妊娠结局的影响[J].新中医,2019,51(10):148-151

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  • 在线发布日期: 2019-10-11
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