重组人干扰素α-2b雾化联合射干麻黄汤治疗小儿毛细支气管炎临床研究
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R725.6

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Clinical Study on Aerosol Inhalation of Recombinant Human Interferon α-2b Combined with Shegan Mahuang Tang for Bronchiolitis in Children
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    摘要:

    目的:观察重组人干扰素α-2b雾化联合射干麻黄汤对毛细支气管炎患儿血清白细胞介素-13(IL-13)、嗜酸性细胞阳离子蛋白(ECP)及外周血T细胞亚群水平的影响。方法:将风寒闭肺证毛细支气管炎患儿220例,随机分为2组各110例,对照组采用重组人干扰素α-2b雾化治疗,观察组在对照组基础上加服射干麻黄汤,观察2组患儿临床疗效、不良反应、血清IL-13、IL-4、ECP、干扰素-γ(IFN-γ) 及T淋巴细胞亚群水平。结果:总有效率观察组为98.18%,对照组为81.82%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组患儿心率复常、住院、气促缓解、咳嗽消失、湿啰音消失及哮鸣音消失时间均短于对照组(P<0.05)。治疗后,2组患儿血清CD3+、CD4+含量及CD4+/CD8+较治疗前上升(P<0.05),血清CD8+含量较治疗前下降(P<0.05);且观察组上述各项指标改善优于对照组(P<0.05)。治疗后,2组血清IL-13、IL-4及ECP含量较治疗前下降(P<0.05),IFN-γ含量较治疗前上升(P<0.05);且观察组上述各项指标改善优于对照组(P<0.05)。治疗过程中2组均未见明显不良反应。结论:射干麻黄汤联合重组人干扰素α-2b雾化治疗风寒闭肺证毛细支气管炎患儿,可有效缓解患儿临床症状,维持Th1/Th2平衡,改善患儿机体免疫功能,疗效优于单纯西药治疗。

    Abstract:

    To observe the effect of aerosol inhalation of recombinant human interferon α-2b combined with Shegan Mahuang tang on the expression levels of serum interleukin-13(IL-13),eosinophil cationic protein(ECP)and T lymphocyte subsets in the peripheral blood of children with bronchiolitis.Methods:Divided 220 cases of children with bronchiolitis and wind-cold invading lung syndrome into two groups randomly,110 cases in each group.The control group received aerosol inhalation of recombinant human interferon α-2b,while the observation group additionally received the oral administration of Shegan Mahuang tang.Observed the clinical effect,adverse reactions and the levels of serum IL-13,IL-4,ECP,interferon-γ(IFN-γ)and T lymphocyte subsets in both group.Results:The total effective rate was 98.18%in the observation group and 81.82%in the control group,difference being significant(P < 0.05).After treatment,the recovery time of heart rate,the time of hospitalization,the remission time of short breath and the disappearance time of coughing,moist rales and wheezing rales in the observation group were all shorter than those in the control group(P < 0.05).After treatment,the contents of serum CD3+,CD4+and the level of CD4+/CD8+in both groups were high than those before treatment(P<0.05),and the content of serum CD8+was lower than that before treatment(P < 0.05);each index above in the observation group was improved better than that in the control group(P < 0.05).After treatment,the contents of serum IL-13,IL-4 and ECP in both groups were lower than those before treatment(P < 0.05),and the content of IFN-γ was high than that in the control group(P < 0.05);each index above in the observation group was improved better than that in the control group(P<0.05).During treatment, no significant adverse reactions occurred in both groups.Conclusion: Shegan Mahuang tang combined with aerosol inhalation of recombinant human interferon α-2b for bronchiolitis in children with wind-cold invading lung syndrome can effectively relieve the clinical symptoms of patients,maintain the balance of Th1/Th2 and improve their bodily immune function.It has better therapeutic effect than simple western medicine.

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史恪勤.重组人干扰素α-2b雾化联合射干麻黄汤治疗小儿毛细支气管炎临床研究[J].新中医,2019,51(10):200-203

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  • 在线发布日期: 2019-10-11
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