补髓生血汤联合环孢素A软胶囊及司坦唑醇片治疗慢性再生障碍性贫血临床研究
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Clinical Study on Busui Shengxue Tang Combined with Cyclosporine A Soft Capsules and Stanzoll Tablets in the Treatment of Chronic Aplastic Anemia
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    摘要:

    目的:探讨补髓生血汤联合西药治疗慢性再生障碍性贫血的临床疗效。方法:将慢性再生障碍性贫血患者65例随机分为2组,对照组32例给予环孢素A软胶囊、司坦唑醇片治疗,观察组33例在对照组的基础上加用补髓生血汤治疗;2组疗程均为6个月,观察比较2组临床疗效及治疗前后各症状(心悸、乏力、头晕、形寒肢冷、面唇指甲、腰膝酸软)评分、血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、碱性成纤维细胞生长因子(bFGF)、Rho家族成员A(Rho-A) 蛋白水平变化情况,并统计2组不良反应情况。结果:总有效率观察组为93.94%,对照组为71.88%,2组比较,差异有统计学意义(P<0.05)。治疗后2组心悸、乏力、头晕、形寒肢冷、面唇指甲及腰膝酸软评分较治疗前降低(P<0.05),且观察组上述各项评分低于对照组(P<0.05)。治疗后2组血清TNF-α、IFN-γ水平较治疗前降低(P<0.05),bFGF、Rho-A水平较治疗前升高(P<0.05);且观察组上述各项指标改善优于对照组(P<0.05)。不良反应发生率观察组为18.18%(6/33),对照组为15.63%(5/32),2组比较,差异无统计学意义(P>0.05)。结论:补髓生血汤配合环孢素A软胶囊、司坦唑醇片治疗慢性再生障碍性贫血效果确切,并可改善患者血清TNF-α、IFN-γ、bFGF、Rho-A水平,且安全性较高。

    Abstract:

    To explore the clinical effect of the therapy of Busui Shengxue Tang combined with cyclosporine A soft capsules and stanzoll tablets in the treatment of chronic aplastic anemia.Methods:A total of 65 patients with chronic aplastic anemia were randomly divided into two groups.Thirty two patients in the control group were treated with cyclosporine A soft capsules and stanzoll tablets.Thirty three patients in the observation group were additionally treated with Busui Shengxue Tang based on the treatment of the control group.Both groups were treated for six months.The clinical effect,the scores of symptoms before and after treatment(palpitations,fatigue,dizziness,cold body and cold extremities,complexion,lips,nails,soreness and weakness of waist and knees),and the changes in the levels of the tumor necrosis factor alpha- α(TNF-α),interferon-γ (IFN- γ),basic fibroblast growth factor(bFGF),member A in Rho family of protein(Rho-A)in serum were observed and compared,and the adverse reactions were statistically analyzed in the two groups.Results:The total effective rate was 93.94%in the observation group and 71.88%in the control group,the difference being significant(P<0.05).After treatment,the scores of palpitations,fatigue,dizziness,cold body and cold extremities,complexion,lips,nails,soreness and weakness of waist and knees were decreased when compared with those before treatment(P < 0.05),and the above scores in the observation group were lower than those in the control group(P < 0.05).After treatment,the levels of TNF-α and IFN-γ in serum were decreased when compared with those before treatment(P < 0.05),while levels of bFGF and Rho-A were increased when compared with those before treatment(P < 0.05),and the improvement of the above indexes in the observation group was better than that in the control group(P<0.05).The incidence of adverse reactions was 18.18%(6/33)in the observation group and 15.63%(5/32)in the control group,there being no statistically significant difference between the two groups(P>0.05).Conclusion:The therapy of Busui Shengxue Tang combined with cyclosporine A soft capsules and stanzoll tablets, has significant effect in treating chronic aplastic anemia, and can improve the levels of TNF-α,IFN-γ,bFGF and Rho-A in serum in patients with high safety.

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郭芳.补髓生血汤联合环孢素A软胶囊及司坦唑醇片治疗慢性再生障碍性贫血临床研究[J].新中医,2019,51(10):204-208

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  • 在线发布日期: 2019-10-11
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