针刺联合丹参注射液治疗新生儿缺血缺氧性脑病临床研究
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Clinical Study on Acupuncture Combined with Danshen Injection in the Treatment of Hypoxic Ischemic Encephalopathy in Neonates
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    摘要:

    目的:观察针刺联合丹参注射液治疗新生儿缺血缺氧性脑病(HIE)的临床疗效。方法:将HIE患儿113例随机分为2组,对照组56例采取针刺治疗,研究组57例在对照组的基础上联合丹参注射液治疗,2组疗程均为15天;统计2组临床疗效、不良反应发生率,观察比较2组治疗前后神经行为评分表(NBNA)评分及红细胞比容、纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度的变化。结果:总有效率研究组为89.47%,对照组为71.43%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组NBNA评分均较治疗前升高(P<0.05),且研究组NBNA评分高于对照组(P<0.05)。治疗后,2组红细胞比容、纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度均较治疗前降低(P<0.05),且研究组上述各项指标均低于对照组(P<0.05)。不良反应发生率研究组为10.53%,对照组为8.93%,2组比较,差异无统计学意义(P>0.05)。结论:丹参注射液联合针刺治疗HIE患儿效果确切,能显著改善其NBNA评分及血液流变学状态,且具有较好安全性。

    Abstract:

    To observe the clinical effect of acupuncture combined with Danshen injection in the treatment of hypoxic ischemic encephalopathy(HIE)in neonates.Methods:A toal of 113 neonates with HIE were randomly divided into two groups.Fifty six cases in the control group were treated with acupuncture,and fifty seven cases in the study group were treated with Danshen injection based on the treatment of the control group.The course of treatment in both groups was fifteen days.The clinical effect and the incidence of adverse reactions were statistically analyzed in the two groups,and the changes in the score of neonatal behaviral neurological assessment(NBNA)and levels of erythrocyte volume,fibrinogen,plasma viscosity,whole blood low-shear viscosity and whole blood high-shear viscosity were observed and compared before and after treatment in the two groups.Results:The total effective rate was 89.47%in the study group and 71.43%in the control group,the difference being significant(P < 0.05).After treatment,NBNA scores in both groups were increased when compared with those before treatment(P < 0.05),and the NBNA score in the study group were higher than that in the control group(P < 0.05).After treatment,the levels of erythrocyte volume,fibrinogen,plasma viscosity,whole blood low-shear viscosity and whole blood high-shear viscosity were all decreased in the two groups when compared with those before treatment(P< 0.05),and the above levels in the study group were lower than those in the control group(P< 0.05).The incidence of adverse reactions was 10.53%in the study group and 8.93%in the control group,there being no statistically significant difference between the two groups(P>0.05).Conclusion:The therapy of Danshen injection combined with acupuncture in effective in treating neonates with HIE,which can significantly improve the neurological behavior and hemorheological indexes with great safety.

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赵梁育,王敏丽,单秋歌.针刺联合丹参注射液治疗新生儿缺血缺氧性脑病临床研究[J].新中医,2019,51(10):256-259

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  • 在线发布日期: 2019-10-11
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