益气养阴散结通络法治疗湿性年龄相关性黄斑变性临床研究
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R774.5

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河北省中医药管理局科研计划项目(2019205)


Clinical Study on Qi-tonifying,Yin-nourishing,Mass-resolving and Collateralsmoothing Method for Wet Age-related Macular Degeneration
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    摘要:

    目的:观察益气养阴散结通络法治疗湿性年龄相关性黄斑变性(AMD)的临床疗效。方法:将65例湿性AMD患者随机分为治疗组34例(39眼)和对照组31例(35眼)。治疗组应用益气养阴散结通络汤治疗,对照组给予七叶洋地黄双苷滴眼液滴眼、和血明目片口服,2组均治疗3个月。观察2组治疗前后视力、视野、黄斑区视网膜厚度及中医证候的改善情况。结果:治疗组总有效率76.92%,高于对照组的62.86%,差异有统计学意义(P<0.05)。治疗后,2组视力均较治疗前上升(P<0.05),治疗组视力优于对照组(P<0.05)。治疗后,2组30°视野均较治疗前增大(P<0.05),治疗组30°视野优于对照组(P<0.05)。治疗后,2组黄斑区视网膜厚度均较治疗前减小(P<0.05),治疗组黄斑区视网膜厚度小于对照组(P<0.05)。治疗组治疗前后视物昏朦、目睛干涩、倦怠乏力、气短懒言、腰膝酸软、心烦失眠积分对比,差异均有统计学意义(P<0.05);对照组上述6项中医证候积分治疗前后比较,差异均无统计学意义(P>0.05);治疗后治疗组上述6项中医证候积分均低于对照组(P<0.05)。结论:益气养阴散结通络法治疗湿性AMD疗效确切。

    Abstract:

    Objective:To observe the clinical effect of qi-tonifying,yin-nourishing,mass-resolving and collateralsmoothing method for wet age-related macular degeneration(AMD).Methods:Divided 65 cases of patients with wet AMD into two groups randomly,34 cases(39 eyes)in the treatment group and 31(35 eyes)cases in the control group.The treatment group received Yiqi Yangyin Sanjie Tongluo tang,while the control group received esculin and digitalisglycosides eye drops via eye dripping and Hexue Mingmu tablets via oral administration.The treatment of both groups lasted for 3 months.Observed the improvements of visual acuity,visual field,macular retinal thickness and Chinese medicine syndrome in both groups before and after treatment.Results:The total effective rate was 76.92% in the treatment group,being higher than 62.86% in the control group,difference being significant(P< 0.05).After treatment,the visual acuity in both groups was higher than that before treatment(P < 0.05),and the visual acuity in the treatment group was better than that in the control group(P < 0.05).After treatment,the 30°visual field in both groups was larger than that before treatment(P < 0.05),and the 30°visual field in the treatment group was better than that in the control group(P < 0.05).After treatment,the macular retinal thickness in both groups was lower than that before treatment(P < 0.05),and the macular retinal thickness in the treatment group was lower than that in the control group(P < 0.05).Comparing the scores of blurred vision,dry eyes,fatigue,short breath and distinclination to talk,distention in knee and waist,upset mind and insomnia in the treatment group before and after treatment,there were significant differences being found(P < 0.05);comparing each Chinese medicine syndrome score above in the control group before and after treatment,there were no significant differences being found(P > 0.05);after treatment,each Chinese medicine syndrome score above in the treatment group was lower than that in the control group(P <0.05).Conclusion:The qi-tonifying,yin-nourishing,mass-resolving and collateral-smoothing method has exact therapeutic effect intreatingwet AMD.

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杨玉青,王慧敏,杨秀荣,王巧玲,王欢,指导:刘玉洁.益气养阴散结通络法治疗湿性年龄相关性黄斑变性临床研究[J].新中医,2020,52(1):126-129

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  • 在线发布日期: 2020-01-06
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