益气养阴活血利水方治疗糖尿病视网膜病变临床研究
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R587.2

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Clinical Study of Yiqi Yangyin Huoxue Lishui Prescription for Diabetic Retinopathy
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    摘要:

    目的:观察益气养阴活血利水方对糖尿病视网膜病变患者脂代谢、血液流变学及血清高敏C-反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、基质细胞衍生因子-1(SDF-1) 水平的影响。方法:选取糖尿病视网膜病变患者116 例,按随机数字表法分为观察组和对照组各58 例。2 组患者均给予常规糖尿病治疗,对照组加用羟苯磺酸钙片治疗,观察组在对照组基础上给予益气养阴活血利水方治疗。比较2 组脂代谢指标、血液流变学指标及血清hs-CRP、VEGF、SDF-1 水平。结果:治疗前,2 组脂代谢指标水平比较,差异无统计学意义(P>0.05)。治疗后,2 组高密度脂蛋白胆固醇(HDL-C) 水平较治疗前升高,低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC) 水平较治疗前下降;且观察组HDL-C 水平高于对照组,LDL-C、TG、TC 水平低于对照组;差异均有统计学意义(P<0.05)。治疗前,2 组血液流变学指标比较,差异无统计学意义(P>0.05)。治疗后,2 组全血高切黏度、全血低切黏度、血浆黏度、血小板聚集率、红细胞变形指数较治疗前下降,且观察组全血高切黏度、全血低切黏度、血浆黏度、血小板聚集率、红细胞变形指数均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2 组血清hs-CRP、SDF-1、VEGF 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组血清hs-CRP、SDF-1、VEGF水平较治疗前降低,且观察组血清hs-CRP、SDF-1、VEGF 水平低于对照组,差异均有统计学意义(P<0.05)。结论:益气养阴活血利水方治疗糖尿病视网膜病变可抑制血清hs-CRP、VEGF、SDF-1 的表达水平,改善患者脂代谢和血液流变学指标,临床疗效较好。

    Abstract:

    Abstract: Objective: To observe the effect of Yiqi Yangyin Huoxue Lishui prescription on lipid metabolism, hemorheology as well as the levels of high-sensitivity C-reactive protein(hs-CRP),vascular endothelial growth factor(VEGF) and stromal cell derived factor- 1(SDF- 1) in serum in patients with diabetic retinopathy. Methods: A total of 116 cases of patients with diabetic retinopathy were divided into the observation group and the control group,58 cases in each group. Both groups were given routine treatment for diabetic;the control group was additionally treated with calcium dobesilate tablets, and the observation group was additionally treated with Yiqi Yangyin Huoxue Lishui prescription based on the treatment of the control group. The indexes of lipid metabolism and hemorheology as well as the levels of hs-CRP,VEGF and SDF-1 in serum were compared between the two groups. Results:Before treatment,there was no significant difference being found in the comparison of the levels of lipid metabolism indexes between the two groups(P>0.05). After treatment,the levels of highdensity lipoprotein cholesterol(HDL-C) in the two groups were increased when compared with those before treatment,and the levels of low- density lipoprotein cholesterol(LDL- C), triglyceride(TG) and total cholesterol(TC) were decreased when compared with those before treatment; the level of HDL- C in the observation group was higher than that in the control group, and the levels of LDL- C, TG and TC were lower; differences were significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of hemorheological indexes between the two groups(P>0.05). After treatment, the whole blood viscosity of high shear, whole blood viscosity of low shear, plasma viscosity, platelet aggregation rate and erythrocyte deformation index in the two groups were decreased when compared with those before treatment,and the above indexes in the observation group were lower than those in the control group,differences being significant(P<0.05). Before treatment, compared the levels of hs- CRP, SDF- 1 and VEGF in serum between the two groups,there was no significance in the difference(P>0.05). After treatment,the levels of hs- CRP,SDF- 1 and VEGF in serum in the two groups were decreased when compared with those before treatment, and the three levels in the observation group were lower than those in the control group, differences being significant(P<0.05). Conclusion: Yiqi Yangyin Huoxue Lishui prescription in treating diabetic retinopathy can inhibit the expression levels of hs- CRP,SDF- 1 and VEGF in serum and improve lipid metabolism,hemorheological indexes,which has good clinical effect.

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侯海敏.益气养阴活血利水方治疗糖尿病视网膜病变临床研究[J].新中医,2020,52(17):84-87

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  • 在线发布日期: 2020-09-06
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