柴胡疏肝散联合草酸艾司西酞普兰治疗肝气郁结型抑郁症临床研究
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R749.4

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Clinical Study on Chaihu Shugan Powder Combined with Escitalopram Oxalate for Depression of Liver Qi Stagnation Type
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    摘要:

    目的:探讨柴胡疏肝散联合草酸艾司西酞普兰对肝气郁结型抑郁症患者去甲肾上腺素(NE)、5-羟色胺(5-HT)水平、社会功能及不良反应的影响。方法:选取96例肝气郁结型抑郁症患者,按随机数字表法分为对照组和治疗组各48例。对照组应用草酸艾司西酞普兰治疗,治疗组在对照组基础上给予柴胡疏肝散口服。比较2组临床疗效、抑郁状况、社会功能、血清NE及5-HT水平、不良反应发生率。结果:治疗组总有效率为95.83%,明显高于对照组81.25%(P<0.05)。治疗前,2组汉密尔顿抑郁量表(HAMD)评分、社会功能缺陷筛选量表(SDSS)评分、SF-36社会功能因子评分比较,差异无统计学意义(P>0.05)。治疗8周后,2组HAMD、SDSS评分较治疗前下降(P<0.05),SF-36社会功能因子评分较治疗前增高(P<0.05);且治疗组HAMD、SDSS评分低于对照组(P<0.05),SF-36社会功能因子评分高于对照组(P<0.05)。治疗前,2组NE、5-HT水平比较,差异无统计学意义(P>0.05)。治疗8周后,2组NE、5-HT水平较治疗前增高(P<0.05),且治疗组NE、5-HT水平高于对照组(P<0.05)。结论:对肝气郁结型抑郁症患者采用柴胡疏肝散联合草酸艾司西酞普兰治疗,临床疗效确切,可显著改善抑郁状况,明显提升血清NE及5-HT水平,有效促进社会功能恢复,且用药安全性高。

    Abstract:

    Objective:To discuss the effect of Chaihu Shugan powder combined with escitalopram oxalate on levels of norepinephrine(NE)and 5-hydroxytryptamine(5-HT),social functioning and adverse reactions in patients with depression of liver qi stagnation type.Methods:Selected 96 cases of patients with depression of liver qi stagnation type,and divided them into the control group and the treatment group randomly,48 cases in each group.The control group received escitalopram oxalate,while the treatment group additionally received the oral administration of Chaihu Shugan powder.Compared the clinical effect,status of depression,social functioning,levels of NE and 5-HT and the incidence of adverse reactions in both groups.Results:The total effective rate was 95.83% in the treatment group,being significantly higher than 81.25% in the control group(P < 0.05).Before treatment,comparing the scores of Hamilton depression rating scale(HAMD),social disability screening schedule(SDSS)and the item of social functioning in SF-36 in both groups,there was no significant difference being found(P>0.05).After treatment for 8 weeks,the scores of HAMD and SDSS in both groups were lower than those before treatment(P < 0.05),and the scores of social functioning in SF-36 were higher than those before treatment(P < 0.05);the scores of HAMD and SDSS in the treatment group were lower than those in the control group(P< 0.05),and the score of social functioning in SF-36 was higher than that in the control group(P< 0.05).Before treatment,comparing the levels of NE and 5-HT in both groups,there was no significant difference being found(P> 0.05).After treatment for 8 weeks,the levels of NE and 5-HT in both groups were higher than those before treatment(P < 0.05),and the levels of NE and 5-HT in the treatment group were higher than those in the control group(P<0.05).Conclusion:The application of Chaihu Shugan powder combined with escitalopram oxalate has exact clinical effect in treating patients with depression of liver qi stagnation type.It can significantly improve the status of depression,evidently increase the levels of NE and 5-HT in serum and effectively promote the recovery of social functioning,which has high safety of medication.

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孙丽霞.柴胡疏肝散联合草酸艾司西酞普兰治疗肝气郁结型抑郁症临床研究[J].新中医,2020,52(2):37-40

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  • 在线发布日期: 2020-01-14
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