Abstract： Objective： To observe the clinical effect of Qingjie tang for acute urticaria(AU) in children and its safety. Methods：A total of 60 cases of AU children were divided into the control group and the study group according to the random number table method，30 cases in each group. The control group was treated with loratadine granules，and the study group was treated with Qingjie tang. The clinical effect， the symptom scores and the incidence of adverse reactions in the two groups were observed and compared. Results：The total clinical effective rate was 90.00% in the study group and 80.00% in the control group， there being no significance in the difference(P＞0.05). Before treatment， there was no significant difference being found in the comparison of the symptom scores between the two groups(P＞0.05). After treatment， the scores of pruritus， wheal， edema and skin lesions in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above symptom scores in the study group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 6.67% in the study group， lower than that of 36.67% in the control group， the difference being significant(P＜0.05). Conclusion： Qingjie tang in treating children with AU can effectively improve the symptom scores and clinical effect，reduce the incidence of adverse reactions and promote the recovery of children.