桂昆风湿合剂联合甲氨蝶呤治疗寒湿痹阻型类风湿关节炎患者骨破坏临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R593.22

基金项目:

中山市科技计划(2017B1053)


Clinical Study on Guikun Fengshi Mixture Combined with Methotrexate for Bone Destruction in Patients with Rheumatoid Arthritis of Cold-dampness Obstruction Type
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察桂昆风湿合剂联合甲氨蝶呤(MTX) 治疗寒湿痹阻型类风湿关节炎(RA) 患者骨破坏的临床疗效。方法:将中山市中医院肾病风湿科门诊及病房90例确诊的RA患者,采用随机数字表法分为观察组、阴性对照组、阳性对照组,每组各30例。观察3组患者不良反应发生情况,Sharp-van der Heijde评分(SHS) 评价关节影像学改善情况,检测β-胶原降解产物(β-CTX) 水平,检测核因子κB 受体活化因子配体(RANKL)、骨保护素(OPG) 和抗酒石酸酸性磷酸酶-5b(TRACP5b) 的水平。结果:治疗12 周后,3 组Sharp 总分、间隙评分、侵蚀评分较治疗前无改善(P>0.05),组间比较,差异无统计学意义(P>0.05)。治疗24周后,观察组关节侵蚀评分较治疗前改善(P<0.05),且观察组关节侵蚀评分低于阴性对照组、阳性对照组(P<0.05)。治疗12 周后,3 组OPG、RANKL、TRACP5b、β-CTX 水平较治疗前改善(P<0.05)。治疗24 周后,3 组OPG、RANKL、TRACP5b、β-CTX 水平较治疗前改善(P<0.05),且观察组OPG、TRACP5b、β-CTX 的水平较其他2组改善,差异有统计学意义(P<0.05)。3组治疗过程中的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:桂昆风湿合剂和MTX联合使用可以改善OPG、RANKL、TRACP5b、β-CTX等RA骨破坏指标,并且在减轻RA患者的关节侵蚀破坏方面更具优势。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Guikun Fengshi mixture combined with methotrexate(MTX) for bone destruction in patients with rheumatoid arthritis(RA) of cold-dampness obstruction type. Methods:A total of 90 cases of PA patients in the department of nephropathy and rheumatism in Zhongshan Hospital of Chinese Medicine were divided into the observation group, the negative control group and the positive control group according to the random number table method,30 cases in each group. The incidence of adverse reactions in the three groups was observed;the improvement of the joint imaging was evaluated by Sharp- van der Heijde score(SHS); and the levels of β- Crosslaps(β- CTX), receptor activator of NF- κB Ligand(RANKL),osteoprotegerin(OPG) and tartrate- resistant acid phosphatase- 5b(TRACP5b) were detected. Results:After 12 weeks of treatment,the total scores of SHS as well as the scores of clearance and erosion in the three groups showed no improvement when compared with those before treatment(P>0.05), and the comparison among the three groups showed no significance in the difference(P>0.05). After 24 weeks of treatment, the score of articular erosion in the observation group was improved when compared with that before treatment(P<0.05),and the above score in the observation group was lower than those in the other two groups(P<0.05). After 12 weeks of treatment, the levels of OPG,RANKL,TRACP5b,and β-CTX in the three groups were improved when compared with those before treatment(P<0.05);after 24 weeks of treatment,the above levels in the three groups were improved when compared with those before treatment(P<0.05),and the levels of OPG,TRACP5b and β-CTX in the observation group were improved when compared with those in the other two groups,the difference being significant(P<0.05). During the treatment,the comparison of the incidence of adverse reactions among the three groups showed no significance in the difference(P>0.05). Conclusion:The therapy of Guikun Fengshi mixture combined with MTX can improve the indexes of bone destruction in RA patients,including OPG,RANKL,TRACP5b and β-CTX,which has more advantages in alleviating the articular erosion and destruction in RA patients.

    参考文献
    相似文献
    引证文献
引用本文

庞捷,徐娟,李李,李燕林.桂昆风湿合剂联合甲氨蝶呤治疗寒湿痹阻型类风湿关节炎患者骨破坏临床研究[J].新中医,2020,52(10):74-77

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2020-05-26
  • 出版日期: