健脾补肾活血方治疗脾肾阳虚证卵巢早衰临床研究
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R711.75

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Clinical Study on Jianpi Bushen Huoxue Prescription for Premature Ovarian Failure with Spleen-kidney Yang Deficiency Syndrome
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    摘要:

    目的:观察健脾补肾活血方治疗脾肾阳虚证卵巢早衰(POF) 的临床疗效。方法:将98例脾肾阳虚证POF患者随机分为对照组和研究组,每组各49例。对照组给予戊酸雌二醇片联合黄体酮胶丸治疗,研究组在对照组的基础上给予健脾补肾活血方治疗;21 d为1个周期,共治疗6个周期;检测2组治疗前后血清促卵泡激素(FSH)、雌二醇(E2)、黄体生成素(LH) 水平,观察2 组绝经期症状和中医证候积分变化,并评估2 组临床疗效和安全性。结果:总有效率研究组为85.71%,对照组为67.35%,2 组比较,差异有统计学意义(P<0.05)。2 治疗后,2 组患者FSH、LH 水平较治疗前下降(P<0.05),E2 水平升高(P<0.05);且研究组上述指标改善较对照组更显著(P<0.05)。与治疗前比较,2组患者治疗后Kupperman评分、中医证候积分均显著下降(P<0.05);且研究组上述评分均低于对照组(P<0.05)。2组患者均未出现严重不适症状和肝肾功能异常改变。结论:在常规西医治疗的基础上联合健脾补肾活血方治疗POF疗效显著,且安全性较高,值得临床推广应用。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Jianpi Bushen Huoxue prescription for premature ovarian failure (POF) with spleen-kidney yang deficiency syndrome. Methods:A total of 98 cases of POF patients with spleen-kidney yang deficiency syndrome were randomly divided into the control group and the study group,49 cases in each group. The control group was treated with estradiol valerate tablets and progesterone soft capsules, and the study group was additionally treated with Jianpi Bushen Huoxue prescription based on the treatment of the control group. Both groups were treated for six cycles,21 days being a cycle. Before and after treatment,the levels of follicle-stimulating hormones(FSH),estradiol(E2) and luteinizing hormone(LH) in serum in the two groups were detected. The changes in the symptoms and Chinese medicine syndrome scores during menopause phase in the two groups were observed, and the clinical effect and safety were evaluated. Results:The total effective rate was 85.71% in the study group,and 67.35% in the control group,the difference being significant(P<0.05). After treatment, the levels of FSH and LH in the two groups were lower than those before treatment(P<0.05),and the level of E2 was higher(P<0.05),and the improvement of the above indexes in the study group was more significant than that in the control group(P<0.05). After treatment,the scores of Kupperman and Chinese medicine syndromes in the two groups were significantly decreased when compared with those before treatment(P<0.05);the above two scores in the study group were lower than those in the control group(P<0.05). There was no severe uncomfortable symptom or abnormal change of the liver and kidney function in the two groups. Conclusion: Based on routine western medicine treatment, Jianpi Bushen Huoxue prescription has significant curative effect in treatment POF with high safety,which is worthy of clinical promotion and application.

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蒋定芬,谢卫琴.健脾补肾活血方治疗脾肾阳虚证卵巢早衰临床研究[J].新中医,2020,52(10):93-96

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  • 在线发布日期: 2020-05-26
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