结核丸对初治涂阳肺结核患者痰菌阴转及IFN-γ、IL-17 水平的影响
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Effect of Jiehe Pills on Sputum Negative Conversion and Levels of IFN-γ and IL-17 in Initial Treatment for Patients with Smear Positive Pulmonary Tuberculosis
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    摘要:

    目的:观察结核丸对初治涂阳肺结核患者痰菌阴转及γ-干扰素(IFN-γ)、白细胞介素-17(IL-17) 水平的影响。方法:选择100例初治涂阳肺结核患者,按随机数字表法分为对照组和观察组各50例。对照组给予常规抗结核药物治疗,观察组在对照组基础上加服结核丸。治疗后2、5、6个月观察比较2组患者的临床症状有效率、痰菌阴转率、病灶吸收率以及血清IFN-γ、IL-17水平,观察2组不良反应发生情况。结果:治疗后2、5个月,观察组临床症状有效率、痰菌阴转率、病灶吸收率高于对照组,差异均有统计学意义(P<0.05);治疗后6个月,观察组临床症状有效率、痰菌阴转率、病灶吸收率略高于对照组,但差异均无统计学意义(P>0.05)。治疗前,2组血清IFN-γ、IL-17水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清IFN-γ水平升高、IL-17水平降低,观察组改善情况优于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为6.0%,对照组为10.0%,2组比较,差异无统计学意义(P>0.05)。结论:结核丸对初治涂阳肺结核患者治疗效果满意,能够促进痰菌阴转及病灶吸收,改善患者的临床症状,并且能够改善患者血清IFN-γ、IL-17水平,临床安全有效。

    Abstract:

    Abstract:Objective:To observe the effect of Jiehe pills on sputum negative conversion and the levels of interferon- γ(IFN- γ) and interleukin- 17(IL- 17) in initial treatment for patients with smear positive pulmonary tuberculosis. Methods: A total of 100 cases of patients with initial treatment for smear positive pulmonary tuberculosis were divided into the control group and the observation group according to the random number table method,50 cases in each group. The control group was treated with routine antituberculosis medicine,and the observation group was additionally treated with Jiehe pills based on the treatment of the control group. In the 2nd,5th,and 6th month after treatment,the effective rate of clinical symptoms,the rate of sputum negative conversion,the focus absorption rate,and the levels of IFN- γ and IL-17 in serum in the two groups were observed and compared. The incidence of adverse reactions in the two groups was observed. Results:In the 2nd and 5th month after treatment,the effective rate of clinical symptoms,the rate of sputum negative conversion and the focus absorption rate in the observation group were higher than those in the control group,differences being significant(P<0.05);in the 6th month after treatment, the above rates in the observation group were slightly higher than those in the control group,but there being no significance in differences(P>0.05). Before treatment,there was no significant difference being found in the comparison of the levels of IFN- γ and IL- 2 in serum between the two groups(P>0.05). After treatment,the levels of IFN-γ in serum in the two groups were increased,and the levels of IL-2 were decreased;the improvement in the observation group was better than that in the control group;differences being significant(P<0.05). The incidence of adverse reactions was 6.0% in the observation group and 10.0% in the control group,there being no significance in differences(P>0.05). Conclusion:Jiehe pills has satisfying curative effect in the initial treatment for patients with smear positive pulmonary tuberculosis,which can promote sputum negative conversion and focus absorption,and improve their clinical symptoms and the levels of IFN-γ and IL-2 in serum,with clinical safety and effectiveness.

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张斌.结核丸对初治涂阳肺结核患者痰菌阴转及IFN-γ、IL-17 水平的影响[J].新中医,2020,52(11):60-63

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  • 在线发布日期: 2020-06-04
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