中医药联合化疗治疗乳腺癌术后疗效Meta 分析
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R737.9

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A Meta-Analysis of Curative Effect of Chinese Medicine Combined with Chemothera⁃ py for Postoperative Breast Cancer
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    摘要:

    目的:系统评价中医药联合化疗对乳腺癌术后患者临床疗效的影响,为乳腺癌术后患者的中医药治疗提供理论依据。方法:计算机全面检索2009年1月1日—2019年5月31日在中国知网(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文摘数据库(CBM)、PubMed、The Cochrane Library等各大数据库,筛选中医药联合化疗与单纯化疗比较对乳腺癌术后患者临床疗效影响的随机对照试验(RCT),对纳入的文献进行系统评价。结果:最终纳入13 项RCT,共1 053 例乳腺癌术后患者,中医药联合化疗组(治疗组) 和单纯化疗组(对照组) 的例数分别为526例和527例。Meta分析结果显示,与对照组比较,治疗组患者术后生活质量、外周血CD3+、CD4+、CD4+/CD8+均提高,白细胞减少发生率、血小板减少发生率、化疗后消化道副反应发生率均降低,差异均有统计学意义(P<0.05)。而2组血红蛋白减少发生率和外周血CD8+比较,差异均无统计学意义(P>0.05)。结论:中医药联合化疗在改善乳腺癌术后的生活质量、减轻化疗毒副反应、提高免疫功能方面均优于单纯化疗。

    Abstract:

    Abstract: Objective: To systematically evaluate the effect of Chinese medicine combined with chemotherapy on patients after surgery for breast cancer,and to provide theoretical basis for the Chinese medicine treatment of postoperative patients with breast cancer. Methods: Computerretrievals on randomized controlled trial(RCT), of comparing the clinical effect of Chinese medicine combined with chemotherapy with that of chemotherapy alone on patients after surgery for breast cancer, were comprehensively conducted from a variety of databases, such as China National Knowledge Infrastructure (CNKI), WANFANG Data, VIP Database for Chinese Technical Periodicals(VIP), China Biology Medicine disc(CBM), PubMed and The Cochrane Library,with retrieval time from January 1st,2009 to May 31st,2019. Enrolled literature was evaluated systematically. Results:A total of 13 RCTs were finally included,involving 1 053 patients after surgery for breast cancer. The number of cases of Chinese medicine combined with chemotherapy(the treatment group) and chemotherapy alone (the control group) was 526 cases and 527 cases respectively. According to meta-analysis result,the treatment group was superior to the control group in increasing the quality of postoperative life of patients,CD3 + cell count in peripheral blood, CD4 + cell count, and CD4 +/CD8 + ratio, as well as in reducing the incidence of leukopenia, thrombocytopenia and gastrointestinal side effect after chemotherapy;differences were significant(P<0.05). However,there was no significance in differences in the incidence of hemoglobin decline and CD8+ cell count in peripheral blood between the two groups(P>0.05). Conclusion:Chinese medicine combined with chemotherapy is superior to chemotherapy alone in improving the quality of life after the operation of breast cancer,alleviating toxic side effects of chemotherapy,and enhancing immune function.

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程权,王舒洁.中医药联合化疗治疗乳腺癌术后疗效Meta 分析[J].新中医,2020,52(13):9-13

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  • 在线发布日期: 2020-07-10
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