银杏叶提取物联合胞磷胆碱钠片治疗急性脑出血临床研究
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R743.3

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Clinical Study on Extract of Folium Ginkgo Combined with Citicoline Sodium Tablets for Acute Cerebral Hemorrhage
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    摘要:

    目的:观察银杏叶提取物联合胞磷胆碱钠片治疗急性脑出血的临床疗效。方法:将急性脑出血患者72 例随机分为2 组,对照组36 例给予胞磷胆碱钠片治疗,治疗组36 例在对照组基础上配合银杏叶提取物治疗;观察比较2 组临床疗效,治疗前后脑血肿、脑水肿体积变化,以及美国国立卫生研究院卒中量表(NIHSS) 评分、日常生活能力量表(ADL) 评分、血清基质金属蛋白酶-9(MMP-9)、S-100β 蛋白、神经元特异性烯醇化酶(NSE) 水平变化,并统计不良反应发生率。结果:总有效率治疗组为91.67%,对照组为63.89%,2 组比较,差异有统计学意义(P<0.05)。治疗后2 组患者血肿体积较治疗前呈缩小趋势;于治疗后第14 天,治疗组血肿体积明显小于对照组(P<0.05)。治疗后2 组患者水肿体积较治疗前呈缩小趋势;于治疗后第7 天、第14 天,治疗组水肿体积均明显小于对照组(P<0.05)。治疗后,2 组患者NHISS 评分均较治疗前明显降低(P<0.05),ADL 评分明显升高(P<0.05);且治疗组两项评分改善均优于对照组(P<0.05)。治疗后2 组MMP-9 水平呈逐渐下降趋势,于治疗后第7 天、第14 天,治疗组明显低于对照组(P<0.05)。治疗后第3 天、第7 天,2 组S-100β 水平均较治疗前上升(P<0.05),但治疗组低于对照组(P<0.05);治疗第14 天,2 组S-100β 水平较治疗前降低(P<0.05),且治疗组S-100β 水平稍低于对照组,但差异无统计学意义(P>0.05)。治疗后2 组NSE 水平逐渐下降趋势,于治疗后第3 天、第7 天,治疗组NSE 水平均低于对照组(P<0.05)。治疗期间2 组均未见明显不良反应发生。结论:银杏叶提取物联合胞磷胆碱钠片治疗急性脑出血临床疗效较好,可降低血清MMP-9、S-100β、NSE 水平,缓解脑水肿,改善神经功能缺损及日常生活能力。

    Abstract:

    Abstract:Objective:To observe the clinical effect of extract of Folium Ginkgo combined with citicoline sodium tablets for acute cerebral hemorrhage. Methods:A total of 72 cases of patients with acute cerebral hemorrhage were randomly divided into two groups,36 cases in each group. The control group was treated with citicoline sodium tablets,and the treatment group was additionally treated with extract of Folium Ginkgo based on the treatment of the control group. The clinical effect and the changes of volume of cerebral hematoma as well as cerebral edema,scores of National Institutes of Health Stroke Scale(NIHSS) as well as Activities of Daily Living(ADL),and levels of matrix metalloproteinase- 9(MMP-9),S-100β protein and neuron-specific enolase(NSE) before and after treatment in the two groups were observed and compared;the incidence of adverse reactions was counted. Results:The total effective rate was 91.67% in the treatment group and 63.89% in the control group, the difference being significant(P<0.05). After treatment, the volumes of cerebral hematoma in the two groups tended to decrease;on the 14th day after treatment,the volume in the treatment group was significantly smaller than that in the control group(P<0.05). After treatment,the volumes of cerebral edema in the two groups were decreased when compared with those before treatment;on the 7th and 14th day after treatment respectively,the volume of cerebral edema in the treatment group was significantly smaller than that in the control group respectively(P<0.05). After treatment,the scores of NHISS in the two groups were significantly decreased when compared with those before treatment(P<0.05),the scores of ADL were significantly increased(P<0.05);the improvement of the above two scores in the treatment group was superior to that in the control group(P<0.05). After treatment,the levels of MMP-9 in the two groups showed a downward trend;on the 7th and 14th day after treatment respectively,the above level in the treatment group was significantly lower than that in the control group(P<0.05). On the 3rd and 7th day after treatment respectively, the levels of S- 100β in the two groups were increased when compared with those before treatment(P<0.05),and the level in the treatment group was lower than that in the control group(P<0.05);on the 14th day after treatment,the levels of S- 100β in the two groups were decreased when compared with those before treatment(P<0.05), and the level in the treatment group was slightly lower than that in the control group,but there being no significant in the difference(P>0.05). After treatment,the levels of NSE in the two groups showed a downward trend,and on the 3rd and 7th day after treatment,the level in the treatment group was lower than that in the control group(P<0.05). No obvious adverse reaction was found in the two groups in the treatment. Conclusion: The therapy of extract of Folium Ginkgo combined with citicoline sodium tablets in treating acute cerebral hemorrhage has good clinical effect, which can reduce levels of MMP- 9, S- 100β and NSE in serum, relieve cerebral edema and improve neurologic impairment and activities of daily living of patients.

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杨义杰.银杏叶提取物联合胞磷胆碱钠片治疗急性脑出血临床研究[J].新中医,2020,52(13):59-63

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  • 在线发布日期: 2020-07-10
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