苏子降气汤合补肺汤加减治疗慢性喘息性支气管炎临床研究
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Clinical Study on Modified Suzi Jiangqi Tang Combined with Bufei Tang for Chronic Asthmatic Bronchitis
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    摘要:

    目的:观察苏子降气汤合补肺汤加减治疗慢性喘息性支气管炎的临床疗效。方法:选取164 例慢性喘息性支气管炎患者,按随机数字表法分为对照组、A 组、B 组和C 组,每组41 例。对照组给予常规西药治疗,A 组给予常规西药+苏子降气汤加减,B 组给予常规西药+补肺汤加减,C 组给予常规西药+苏子降气汤+补肺汤加减。比较4 组临床疗效、治疗前后症状评分变化、肺功能变化、不良反应和随访期复发率。结果:对照组总有效率为60.98%,A 组为80.49%,B 组为80.49%,C 组为97.56%,4 组总有效率比较,C 组>A/B 组>对照组(P<0.05)。治疗前,4 组咳嗽、咳痰、喘息、哮鸣音症状评分比较,差异均无统计学意义(P>0.05)。治疗后,4 组咳嗽、咳痰、喘息、哮鸣音症状评分均较治疗前降低(P<0.05),且4 组各项症状评分比较,C 组<A/B 组<对照组(P<0.05)。治疗前,4 组第1 秒用力呼气容积占预计值的百分比(FEV1%) 和第1 秒钟用力呼气容积占用力肺活量比值(FEV1/FVC) 比较,差异均无统计学意义(P>0.05)。治疗后,4 组FEV1%和FEV1/FVC 较治疗前提高(P<0.05),且4 组FEV1%和FEV1/FVC 比较,C 组>A/B 组>对照组(P<0.05)。对照组不良反应发生率为4.88%,A 组为7.32%,B 组为9.76%,C 组为14.63%,4 组不良反应发生率比较,差异无统计学意义(P>0.05)。对照组复发率为40.00%,A 组为24.24%,B 组为24.24%,C 组为0,C 组复发率显著低于其他3 组(P<0.05)。结论:对慢性喘息性支气管炎患者在常规西药的基础上给予苏子降气汤加减、补肺汤加减均可减轻症状,增强疗效,改善肺功能,二者合用加减治疗的作用和效果更佳,还可显著降低复发率,且不会增加不良反应。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Suzi Jiangqi tang combined with Bufei tang for chronic asthmatic bronchitis. Methods:A total of 164 cases of patients with chronic asthmatic bronchitis were selected and divided into the control group, Group A, B and C according to the random number table method, 41 cases in each group. The control group was given routine western medicine. Based on the treatment of the control group,Group A was additionally given modified Suzi Jiangqi tang; Group B was additionally given modified Bufei tang; Group C was additionally given modified Suzi Jiangqi tang combined with Bufei tang. The clinical effect, the changes in symptom scores and the lung function,the adverse reactions and recurrence rate during the follow-up period before and after treatment were compared between the four groups. Results:The total effective rate was 60.98% in the control group,80.49% in Group A and B as well as 97.56% in Group C. The total effective rate in Group C was higher than that in Group A and B,and the rate in Group A and B was higher than that in the control group(P<0.05). Before treatment,when compared the symptom scores including cough, expectoration, dyspnea and wheezing sound between the four groups, there was no significance in differences (P>0.05);after treatment,the above symptom scores in the four groups were decreased when compared with those before treatment(P<0.05),and the symptom scores in Group C were lower than those in Group A and B,and the scores in Group A and B were lower than those in the control group(P<0.05). Before treatment, when compared the one second forced expiratory volume as a percentage of the expected value(FEV1%) and one second forced expiratory volume occupying force vital capacity ratio(FEV1/FVC) between the four groups, there was no significance in differences(P>0.05). After treatment, the FEV1% and FEV1/FVC in the four groups were increased when compared with those before treatment(P<0.05). The FEV1% and FEV1/FVC in Group C were higher than those in Group A and B,and the above percentage and ratio in Group A and B were higher than those in the control group(P<0.05). The incidence of adverse reactions was 4.88% in the control group, 7.32% in Group A,9.76% in Group B as well as 14.63% in Group C,and when compared with that among the four groups, there was no significance in differences(P>0.05). The recurrence rate was 40.00% in the control group,24.24% in Group A and B as well as 0 in Group C, and the rate in Group C was significantly lower than those in other three groups(P<0.05). Conclusion:Based on routine western medicine,the additional therapy of modified Suzi Jiangqi tang and modified Bufei tang for patients with chronic asthmatic bronchitis,can reduce symptoms,strengthen the curative effect and improve the lung function. The combined treatment of the two modified tangs has better function and effect,which can significantly reduce the recurrence rate. Besides,adverse reactions will not increased.

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盛梅梅,吴秋枫,方子燕.苏子降气汤合补肺汤加减治疗慢性喘息性支气管炎临床研究[J].新中医,2020,52(14):51-55

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  • 在线发布日期: 2020-07-20
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