丹参注射液联合前列地尔治疗糖尿病肾病临床疗效及安全性Meta 分析
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R587.2;R692.9

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Meta Analysis of Clinical Effect and Safety of Danshen Injection Combined with Alprostadil for Diabetic Nephropathy
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    摘要:

    目的:系统评价丹参注射液联合前列地尔治疗糖尿病肾病(DN) 的临床疗效及安全性。方法:通过计算机检索中国知网(CNKI)、万方数据库(WANFANG)、维普中文生物医学期刊数据库(CMJD)、中国生物医学文献数据库(CBM)、Cochrane Library 及PubMed 数据库中自建库至2019 年6 月1 日报道的与丹参注射液联合前列地尔治疗DN 的随机对照试验(RCT)。由2 名研究者各自独立进行文献筛选、提取资料、文献质量评价,运用RevMan5.3 软件进行Meta 分析。结果:最终纳入9 项RCT,共计742 例患者。丹参注射液联合前列地尔治疗DN 的临床有效率、肌酐(Cr)、尿素氮(BUN)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、尿白蛋白排泄率(UAER) 等指标均优于单独应用前列地尔(P<0.05)。结论:丹参注射液联合前列地尔治疗DN 的临床疗效及安全性均优于单用前列地尔。

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    Abstract: Objective: To systematically evaluate the clinical effect and safety of Danshen injection combined with alprostadil for diabetic nephropathy(DN). Methods: Randomized Controlled Trials(RCT) of Danshen injection combined with alprostadil for DN were carried out by computer retrieval on China National Knowledge Infrastructure(CNKI), Wanfang Database(WANFANG), VIP Chinese Medical Journal Database(CMJD), China Biomedical Literature Database(CBM), Cochrane Library and PubMed Database from their constructions to June 1,2019. Literature screening,data extraction and quality evaluation of literature were performed by two researchers independently and respectively. RevMan5.3 software was applied to carry out meta analysis. Results:Finally,9 RCTs were included,with a total of 742 patients. When compared with the indexes of clinical effective rate,creatinine(Cr),blood urea nitrogen(BUN),total cholesterol(TC),triglyceride(TG),lowdensity lipoprotein(LDL), high- density lipoprotein(HDL) and urinary albumin excretion rate(UAER), the therapy of Danshen injection combined with alprostadil for DN was better than simple application of alprostadil. Conclusion: The therapy of Danshen injection combined with alprostadil for DN has better clinical effect and safety than simple application of alprostadil.

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魏远清,陈静.丹参注射液联合前列地尔治疗糖尿病肾病临床疗效及安全性Meta 分析[J].新中医,2020,52(16):16-20

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  • 在线发布日期: 2020-08-19
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