Objective：To observe the clinical effect of platelet-rich plasma(PRP)for ankle injury.Methods：Selected 69 cases of patients with ankle injury，and divided them into two groups randomly，32 cases in the control group and 33 cases in the observation group.Both groups were given etoricoxib tablets orally daily for treatment.The control group was additionally given intra-articular injection with sodium hyaluronate，while the observation group was given intra-articular injection with PRP.Compared Baird-Jackson ankle joint score and visual analogue scale(VAS)in the two groups before treatment and on the third，sixth and twelfth month after treatment.Evaluated ankle joint function and the clinical effect and observed the occurrence of adverse reactions.Results：Compared the Baird-Jackson ankle joint score on the third，sixth and twelfth month after treatment in the two groups with those before treatment respectively，differences were significant(P＜0.05).The comparisons of the Baird-Jackson ankle joint score on the third and sixth month after treatment between the two groups showed significance in differences(P＜0.05).No significant difference was found in the comparison of the Baird-Jackson ankle joint score on the twelfth month after treatment between the two groups(P＜0.05).Compared the VAS on the third，sixth and twelfth month after treatment in the two groups with those before treatment respectively，differences were significant(P＜0.05).The comparisons of VAS on the third，sixth and twelfth month after treatment between the two groups showed significance in differences(P＜0.05).Conclusion：PRP can effectively improve ankle function，improve the curative effect and relieve pain of patients with ankle injury when they do not receive operation.