Abstract：Objective：To observe the clinical effect of Jiaotai pills combined with Wuling capsules for insomnia of heartkidney noninteraction type. Methods：A total of 100 cases of patients with insomnia of heart-kidney noninteraction type were selected and divided into the control group and the observation group according to the random number table method， 50 cases in each group. The control group was treated with Wuling capsules and the observation group was additionally treated with Jiaotai pills based on the treatment of the control group. The changes in scores of Pittsburgh Sleep Quality Index(PSQI)， insulin resistance，fasting blood glucose (FBG) and postprandial 2 h blood glucose(P2hBG) in the two groups were compared； the clinical effect and the incidence of adverse reactions in the two groups were observed. Results：The total effective rate was 96.00% in the observation group， higher than that of 80.00% in the control group(P＜0.05). After treatment， the individual and total scores of PSQI in the two groups were decreased， and the individual and total scores of PSQI in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the levels of insulin resistance index(HOMA-IR) and serum adiponectin in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of FBG and P2hBG in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above levels in the observation group were lower than those in the control group(P＜ 0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： The application of Jiaotai pills combined with Wuling capsules has good clinical effect in treating patients with insomnia of heart- kidney noninteraction type， which can improve insulin resistance， promote the recovery of blood glucose and enhance sleep quality with medication safety.